Enhanced Carbonyl Stress and Disrupted White Matter Integrity in Schizophrenia.
Enhanced Carbonyl Stress and Disrupted White Matter Integrity in Schizophrenia.
复制标题
精神分裂症中羰基应激的增强和白质完整性的破坏。
DOI：
10.1016/j.schres.2020.08.007
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发表时间：
2020
期刊：
影响因子：
4.5
通讯作者：
Murai T.
中科院分区：
文献类型：
--
作者：
Son S;Arai M;Toriumi K;Mizuta H;Miyata J;Hayashi T;Aso T;Itokawa M;Murai T.
羰基应激是由于富含活性羰基化合物（RCO）增加而引起的一种状态； RCO 促进晚期糖基化终末产物 (AGE) 的形成，AGE 与各种年龄相关疾病有关。最近，研究表明，羰基应激的增强和吡哆醛（一种清除 RCO 的维生素 B6）水平的降低与精神分裂症有关。同时，据报道，较低水平的吡哆醛可通过羰基应激的生化过程减少髓鞘形成。尽管有许多关于精神分裂症白质破坏的报道，但尚不清楚这种破坏是否与羰基应激增强有关。因此，我们利用扩散张量成像研究了精神分裂症中羰基应激与白质完整性之间的关系。总共招募了 53 名精神分裂症患者和 83 名年龄和性别匹配的健康对照者。我们使用血浆戊糖苷、AGE 和血清吡哆醛作为羰基应激标记物。使用基于束的空间统计研究了这些羰基应激标记的组间差异及其与白质完整性的关系。精神分裂症组血浆戊糖素水平显着高于对照组，血清吡哆醛水平显着低于对照组。精神分裂症组血浆戊糖素与白质完整性呈显着负相关，而对照组则不然。我们的研究结果表明，增强的羰基应激可能是精神分裂症白质微结构破坏的潜在机制。
Carbonyl stress is a state caused by an increase in rich reactive carbonyl compounds (RCOs); RCOs facilitate the formation of advanced glycation end products (AGEs), which are associated with various age-related illnesses. Recently, enhanced carbonyl stress and lower levels of pyridoxal, a kind of vitamin B6 that scavenges RCOs, have been shown to be associated with schizophrenia. Meanwhile, lower levels of pyridoxal have been reported to decrease myelination through the biochemical process of carbonyl stress. Despite a number of reports on white matter disruption in schizophrenia, it is unclear whether this disruption is related to enhanced carbonyl stress. Therefore, we investigated the relationship between carbonyl stress and white matter integrity in schizophrenia using diffusion tensor imaging. A total of 53 patients with schizophrenia and 83 age- and gender-matched healthy controls were recruited. We used plasma pentosidine, an AGE, and serum pyridoxal as carbonyl stress markers. Between-group differences in these carbonyl stress markers and their relationships with white matter integrity were investigated using Tract-Based Spatial Statistics. In the schizophrenia group, plasma pentosidine level was significantly higher and serum pyridoxal level was lower than those of controls. There was a significant negative correlation between plasma pentosidine and white matter integrity in the schizophrenia group, but not in the control group. Our findings suggest that enhanced carbonyl stress is a possible underlying mechanism of white matter microstructural disruption in schizophrenia.