Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study
Brain tumour risk in relation to mobile telephone use: results of the INTERPHONE international case-control study
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DOI：
10.1093/ije/dyq079
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发表时间：
2010-06-01
影响因子：
7.7
通讯作者：
Schoemaker, M. J.
中科院分区：
文献类型：
--
作者：
Cardis, E.;Deltour, I.;Schoemaker, M. J.
方法 在13个国家使用通用方案进行了一项基于访谈的病例对照研究，涉及2708例胶质瘤和2409例脑膜瘤病例以及匹配的对照。
结果 对于胶质瘤[比值比（OR）为0.81；95%置信区间（CI）为0.70 - 0.94]和脑膜瘤（OR为0.79；95% CI为0.68 - 0.91），观察到与曾经经常使用手机相关的比值比降低，这可能反映了参与偏倚或其他方法学局限性。在首次使用手机≥10年后未观察到比值比升高（胶质瘤：OR为0.98；95% CI为0.76 - 1.26；脑膜瘤：OR为0.83；95% CI为0.61 - 1.14）。对于终生通话次数的所有十分位数以及累积通话时间的九个十分位数，比值比均＜1.0。在回忆的累积通话时间的第10个十分位数（≥1640小时），胶质瘤的比值比为1.40（95% CI为1.03 - 1.89），脑膜瘤的比值比为1.15（95% CI为0.81 - 1.62）；但该组报告的使用情况存在不合理的值。胶质瘤的比值比在颞叶往往比在大脑的其他叶更高，但叶特异性估计值周围的置信区间较宽。在报告通常在头部与肿瘤同侧使用手机的受试者中，胶质瘤的比值比往往比在对侧使用的更高。
结论 总体而言，未观察到使用手机会增加胶质瘤或脑膜瘤的风险。有迹象表明在最高暴露水平下胶质瘤风险增加，但偏倚和误差妨碍了因果解释。长期大量使用手机的可能影响需要进一步研究。
Methods An interview-based case-control study with 2708 glioma and 2409 meningioma cases and matched controls was conducted in 13 countries using a common protocol.Results A reduced odds ratio (OR) related to ever having been a regular mobile phone user was seen for glioma [OR 0.81; 95% confidence interval (CI) 0.70-0.94] and meningioma (OR 0.79; 95% CI 0.68-0.91), possibly reflecting participation bias or other methodological limitations. No elevated OR was observed >= 10 years after first phone use (glioma: OR 0.98; 95% CI 0.76-1.26; meningioma: OR 0.83; 95% CI 0.61-1.14). ORs were < 1.0 for all deciles of lifetime number of phone calls and nine deciles of cumulative call time. In the 10th decile of recalled cumulative call time, >= 1640 h, the OR was 1.40 (95% CI 1.03-1.89) for glioma, and 1.15 (95% CI 0.81-1.62) for meningioma; but there are implausible values of reported use in this group. ORs for glioma tended to be greater in the temporal lobe than in other lobes of the brain, but the CIs around the lobe-specific estimates were wide. ORs for glioma tended to be greater in subjects who reported usual phone use on the same side of the head as their tumour than on the opposite side.Conclusions Overall, no increase in risk of glioma or meningioma was observed with use of mobile phones. There were suggestions of an increased risk of glioma at the highest exposure levels, but biases and error prevent a causal interpretation. The possible effects of long-term heavy use of mobile phones require further investigation.