The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
The phytopathogenic bacteria Erwinia carotovora infects Drosophila and activates an immune response
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DOI：
10.1073/pnas.070357597
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发表时间：
2000-03-28
影响因子：
11.1
通讯作者：
Lemaitre, B
中科院分区：
文献类型：
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作者：
Basset, A;Khush, RS;Lemaitre, B
虽然果蝇具有很强的免疫应答能力，但对感染果蝇的病原微生物却知之甚少。我们已经鉴定了欧文氏菌属的成员，它们在果蝇幼虫摄食后诱导编码抗菌肽的基因的系统表达。我们的数据表明，这些菌株还进化出了利用其昆虫载体作为宿主的机制。欧文氏菌感染诱导果蝇幼虫的抗菌反应与抗菌肽编码基因的优先表达。在两个果蝇突变体中，欧文氏菌感染后的抗菌肽基因表达减少，这表明血细胞在调节果蝇抗菌反应中起作用，也说明了果蝇-欧文氏菌相互作用为解剖宿主-病原体关系提供了一个强大的模型。
Although Drosophila possesses potent immune responses, little is known about the microbial pathogens that infect Drosophila, We have identified members of the bacterial genus Erwinia that induce the systemic expression of genes encoding antimicrobial peptides in Drosophila larvae after ingestion, These Erwinia strains are phytopathogens and use flies as vectors; our data suggest that these strains have also evolved mechanisms for exploiting their insect vectors as hosts. Erwinia infections induce an antimicrobial response in Drosophila larvae with a preferential expression of antibacterial versus antifungal peptide-encoding genes. Antibacterial peptide gene expression after Erwinia infection is reduced in two Drosophila mutants that have reduced numbers of hemocytes, suggesting that blood cells play a role in regulating Drosophila antimicrobial responses and also illustrating that this Drosophila-Erwinia interaction provides a powerful model for dissecting host-pathogen relationships.