Antiretroviral therapy adherence among patients living with HIV/AIDS in Thailand.
Antiretroviral therapy adherence among patients living with HIV/AIDS in Thailand.
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DOI：
10.1111/j.1442-2018.2010.00521.x
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发表时间：
2010-06
影响因子：
2.7
通讯作者：
Jiraphongsa C
中科院分区：
文献类型：
--
作者：
Li L;Lee SJ;Wen Y;Lin C;Wan D;Jiraphongsa C
艾滋病毒/艾滋病患者坚持接受抗逆转录病毒治疗的重要性已得到充分证明。尽管有这一迫切需要，但许多人没有遵循规定的方案。为了检查导致不依从的障碍，我们使用了泰国北方和东北部随机对照干预试验的横断面调查数据。在参加试验的507名患者中，我们分析了386名接受抗逆转录病毒治疗的患者，以检查依从性的障碍。除了人口统计学特征，抑郁症状，身体健康，获得护理，社会支持，和内在的羞耻，艾滋病毒的披露和家庭沟通进行了检查。相关性分析显示，坚持与内化羞耻，获得护理，抑郁症状和家庭沟通显着相关。基于多元逻辑回归分析，抑郁症状（p <0.03）、获得护理（p <0.02）、HIV披露（p <0.03）和家庭沟通（p <0.03）是依从性的重要预测因素。有抑郁症状仍然是坚持的一个重大障碍，而获得护理，艾滋病毒披露和家庭沟通发挥重要的积极作用。我们的研究结果强调了解决这些可能影响依从性的各种挑战的至关重要性。
The importance of antiretroviral therapy adherence for patients living with HIV/AIDS has been well documented. Despite this critical need, many do not follow prescribed regimens. To examine barriers that lead to non-adherence, we used a cross-sectional survey data from a randomized controlled intervention trial in the northern and northeastern Thailand. Of the 507 patients enrolled in the trial, we analyzed 386 patients on antiretroviral therapy to examine the barriers to adherence. In addition to demographic characteristics, depressive symptoms, physical health, access to care, social support, and internalized shame, HIV disclosure and family communication were examined. Correlation analysis revealed that adherence is significantly associated with internalized shame, access to care, depressive symptoms, and family communication. Based on the multiple logistic regression analysis, depressive symptoms (p < .03), access to care (p < .02), HIV disclosure (p < .03), and family communication (p < .03) were significant predictors of adherence. Having depressive symptoms remains a significant barrier to adherence, while access to care, HIV disclosure, and family communication play important positive roles. Our findings underscore the critical importance of addressing these various challenges that may influence adherence.
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发表时间：
2007-10-01
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