Repeated cross-sectional sero-monitoring of SARS-CoV-2 in New York City
Repeated cross-sectional sero-monitoring of SARS-CoV-2 in New York City
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DOI：
10.1038/s41586-020-2912-6
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发表时间：
2020-11-03
期刊：
影响因子：
64.8
通讯作者：
Krammer, Florian
中科院分区：
文献类型：
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作者：
Stadlbauer, Daniel;Tan, Jessica;Krammer, Florian
早在2月中旬，在纽约市西奈山医院的患者中就检测到了SARS-CoV-2血清阳性样本，在第一波大流行期间抗体阳性率上升，之后保持稳定。2019年底，中国首次检测到严重急性呼吸系统综合征冠状病毒2型（SARS-CoV-2），此后引发了2019冠状病毒病（COVID-19）大流行。纽约市的首例COVID-19病例于二零二零年三月一日正式确认，随后当地爆发严重疫情（1）。在这里，为了了解血清阳性率动态，我们从2020年2月初到7月，每周间隔一次，使用纽约市西奈山医院患者的1万多份血浆样本，对抗SARS-CoV-2刺突抗体进行回顾性、重复性横断面分析。我们描述了“紧急护理”组和“常规护理"组的血清阳性率动态，前者在疫情期间富含COVID-19病例，后者更接近于代表一般人群。两组的血清阳性率均有不同程度的上升;早在2月中旬就发现了血清阳性样本，在5月底流行浪潮平息后，两组的血清阳性样本均稳定在略高于20%的水平。从5月到7月，血清阳性率保持稳定，表明人群中的抗体水平持续存在。我们的数据表明，SARS-CoV-2在纽约市的引入早于以前的记录，并描述了在大都市地区的第一波大流行的整个过程中的血清转换的动态。
Seropositive samples of SARS-CoV-2 were detected as early as mid-February in patients at Mount Sinai Hospital in New York City, and antibody positivity increased during the first wave of the pandemic and remained stable afterwards.In late 2019, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first detected in China and has since caused a pandemic of coronavirus disease 2019 (COVID-19). The first case of COVID-19 in New York City was officially confirmed on 1 March 2020 followed by a severe local epidemic(1). Here, to understand seroprevalence dynamics, we conduct a retrospective, repeated cross-sectional analysis of anti-SARS-CoV-2 spike antibodies in weekly intervals from the beginning of February to July 2020 using more than 10,000 plasma samples from patients at Mount Sinai Hospital in New York City. We describe the dynamics of seroprevalence in an 'urgent care' group, which is enriched in cases of COVID-19 during the epidemic, and a 'routine care' group, which more closely represents the general population. Seroprevalence increased at different rates in both groups; seropositive samples were found as early as mid-February, and levelled out at slightly above 20% in both groups after the epidemic wave subsided by the end of May. From May to July, seroprevalence remained stable, suggesting lasting antibody levels in the population. Our data suggest that SARS-CoV-2 was introduced in New York City earlier than previously documented and describe the dynamics of seroconversion over the full course of the first wave of the pandemic in a major metropolitan area.