Research using Mesenchymal Stem/Stromal Cells: quality metric towards developing a reference material.
Research using Mesenchymal Stem/Stromal Cells: quality metric towards developing a reference material.
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DOI：
10.1016/j.jcyt.2015.07.008
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发表时间：
2015-09
期刊：
影响因子：
4.5
通讯作者：
Pochampally RR
中科院分区：
文献类型：
--
作者：
Tanavde V;Vaz C;Rao MS;Vemuri MC;Pochampally RR
Mesenchymal stem/stromal cells (MSCs) have been extensively investigated for their regenerative, immune-modulatory, and wound healing properties. While the laboratory studies have suggested that MSC’s have a unique potential for modulating the etiopathology of multiple diseases, the results from clinical trials have not been encouraging or reproducible. One of the explanations for such variability is explained by the “art” of isolating and propagating MSCs. Therefore, establishing more than minimal criteria to define MSC would help understand best protocols to isolate, propagate and deliver MSCs. Developing a calibration standard, a database and a set of functional tests would be a better quality metric for MSCs. In this review, we discuss the importance of selecting a standard, issues associated with coming up with such a standard and how these issues can be mitigated.
