Association between salivary oxytocin levels and the amygdala and hippocampal volumes
Association between salivary oxytocin levels and the amygdala and hippocampal volumes
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DOI：
10.1007/s00429-022-02543-5
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发表时间：
2022-08-09
影响因子：
3.1
通讯作者：
Takagishi，Haruto
中科院分区：
文献类型：
--
作者：
Shou，Qiulu;Yamada，Junko;Takagishi，Haruto
唾液催产素水平由于操作简单和非侵入性，已被广泛测量和研究与社会行为的关系。虽然血液中催产素水平与海马体和杏仁核之间的关系现在已经变得清晰起来，但很少有研究探讨唾液催产素与大脑功能和结构的关系。这项研究旨在调查178名成年人(92名女性和86名男性)的唾液催产素水平是否与杏仁核和海马体的体积有关。我们使用Freesurver对杏仁核和海马体进行了体积分析，并使用酶联免疫吸附试验测量了唾液中催产素的水平。结果表明，唾液催产素水平对不同性别杏仁核体积的影响相互矛盾，而对海马体体积没有显著影响。具体地说，男性唾液催产素水平与杏仁核体积呈正相关，而女性唾液催产素水平与杏仁核体积呈负相关。这项研究发现，唾液催产素和大脑结构之间的关联存在性别差异，这一发现支持了之前的研究结果，即催产素系统存在性别差异。
Salivary oxytocin levels have been widely measured and studied in relation to social behavior because of procedural simplicity and noninvasiveness. Although the relationship between oxytocin levels in the blood and the hippocampus and amygdala is now becoming clear with reliable blood oxytocin studies, few studies have examined the relationship between salivary oxytocin and the brain function and structure. This study aimed to investigate whether the salivary oxytocin level is associated with the volume of the amygdala and hippocampus in 178 adults (92 women and 86 men) in their third to seventh decade of life. We performed volumetric analysis of the amygdala and hippocampus using FreeSurfer and measured salivary oxytocin levels using enzyme-linked immunosorbent assay. The results showed contradictory effects of the salivary oxytocin level on the amygdala volume by sex and no significant effect on the hippocampal volume. Specifically, men showed a positive correlation between the salivary oxytocin level and amygdala volume, whereas women showed a negative correlation between the salivary oxytocin level and amygdala volume. The present study’s finding of sex differences in the association between salivary oxytocin and brain structure supports previous findings that there are sex differences in the oxytocin system.