MOXIDECTIN AGAINST IVERMECTIN-RESISTANT NEMATODES - A GLOBAL VIEW
MOXIDECTIN AGAINST IVERMECTIN-RESISTANT NEMATODES - A GLOBAL VIEW
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DOI：
10.1111/j.1751-0813.1994.tb00895.x
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发表时间：
1994-01-01
影响因子：
1.1
通讯作者：
KIERAN, PJ
中科院分区：
文献类型：
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作者：
KIERAN, PJ
大环内酯类杀菌剂包括两种化学上不同的化合物莫西菌素，一种米贝霉素，以及伊维菌素，一种阿维菌素。这些化合物之间的化学差异与线虫抗性有关的意义仍有待确定。报道的研究表明，推荐剂量率为0.2毫克/公斤的莫西菌素对照鉴定出从绵羊和山羊分离出的线虫菌株对伊维菌素表现出抗药性。这反映了莫西菌素对3个线虫属的明显更强的效力，这3个属最常涉及驱虫药抗性的线虫，即血吸虫、奥斯特塔格线虫和毛线虫。在推荐的战略治疗方案中，莫西菌素应可降低对大环内酯类杀菌剂进一步产生抗药性的风险。
Macrocyclic lactone endectocides include two chemically distinct compounds moxidectin, a milbemycin, and ivermectin, an avermectin. The significance of the chemical differences between these compounds in relation to nematode resistance remains to be established. Reported studies indicate that moxidectin at the recommended dose rate of 0.2 mg/kg controls identified strains of nematodes, isolated from sheep and goats, with demonstrated resistance to ivermectin. This reflects the significantly greater potency of moxidectin against the 3 genera of nematodes most commonly involved in anthelmintic resistance, Haemonchus, Ostertagia and Trichostrongylus. Moxidectin, in recommended strategic treatment programmes, should reduce the risk of further development of resistance to the macrocylic lactone endectocides.