Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers.
Altered engagement of autobiographical memory networks in adult offspring of postnatally depressed mothers.
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DOI：
10.1016/j.biopsycho.2016.05.006
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发表时间：
2016-07
影响因子：
2.6
通讯作者：
Johnstone T
中科院分区：
文献类型：
--
作者：
Macdonald B;Murray L;Moutsiana C;Fearon P;Cooper PJ;Halligan SL;Johnstone T
我们研究了患有产后抑郁症（PND）的母亲的年轻成年后代。我们研究了涉及母亲的自传体记忆的前额叶调节。PND后代的差异只发现了愉快的记忆回忆。前额叶与后扣带回和楔前叶的连接减少。这种机制可能会增加PND母亲后代的精神病理学风险。母亲抑郁与后代情绪和焦虑障碍的风险增加有关。母亲抑郁对后代发育的一个可能影响是情感自传体记忆系统。我们研究了与对照组（N = 21）相比，患有产后抑郁症的母亲（N = 16）的成年后代的情感自传体记忆的神经机制。在功能磁共振成像过程中，参与者描述了一个愉快的和一个不愉快的情况与他们的母亲和同伴的录音，被用来作为提示重新生活的情况。与对照组相比，我们预测PND后代将显示：与自传体记忆和反刍有关的内侧和后部大脑区域的激活更大;外侧前额叶皮层的激活减少，外侧前额叶和后部区域之间的连接减少，反映了对自传体回忆的控制减少。对于消极的情况，我们没有发现组间差异。在与母亲的积极情境中，PND子代的左侧前额叶、右侧额极、扣带回和楔前叶的激活高于对照组，而右侧额中回、左侧颞中回、丘脑和舌回与后扣带回的连通性低于对照组。我们的研究结果是一致的成年后代PND母亲有效率较低的前额叶调节个人相关的愉快的自传体记忆。
We studied young adult offspring of mothers with postnatal depression (PND). We examined prefrontal regulation of autobiographical memories involving the mother. PND offspring differences were only found for recall of pleasant memories. There was reduced prefrontal connectivity with posterior cingulate and precuneus. This mechanism might increase risk for psychopathology in offspring of PND mothers. Maternal depression is associated with increased risk for offspring mood and anxiety disorders. One possible impact of maternal depression during offspring development is on the emotional autobiographical memory system. We investigated the neural mechanisms of emotional autobiographical memory in adult offspring of mothers with postnatal depression (N = 16) compared to controls (N = 21). During fMRI, recordings of participants describing one pleasant and one unpleasant situation with their mother and with a companion, were used as prompts to re-live the situations. Compared to controls we predicted the PND offspring would show: greater activation in medial and posterior brain regions implicated in autobiographical memory and rumination; and decreased activation in lateral prefrontal cortex and decreased connectivity between lateral prefrontal and posterior regions, reflecting reduced control of autobiographical recall. For negative situations, we found no group differences. For positive situations with their mothers, PND offspring showed higher activation than controls in left lateral prefrontal cortex, right frontal pole, cingulate cortex and precuneus, and lower connectivity of right middle frontal gyrus, left middle temporal gyrus, thalamus and lingual gyrus with the posterior cingulate. Our results are consistent with adult offspring of PND mothers having less efficient prefrontal regulation of personally relevant pleasant autobiographical memories.