HEPATIC ANTIOXIDANT ENZYMES AND LIPID-PEROXIDATION IN CARBON TETRACHLORIDE-INDUCED LIVER-CIRRHOSIS IN RATS
HEPATIC ANTIOXIDANT ENZYMES AND LIPID-PEROXIDATION IN CARBON TETRACHLORIDE-INDUCED LIVER-CIRRHOSIS IN RATS
复制标题
DOI：
10.1016/0885-4505(88)90102-8
复制
发表时间：
1988-08-01
期刊：
影响因子：
--
通讯作者：
DSOUZA, NB
中科院分区：
文献类型：
--
作者：
NADKARNI, GD;DSOUZA, NB
通过口服苯巴比妥和吸入四氯化碳蒸气的联合作用诱发大鼠肝硬化。这些大鼠表现出肝脾肿大、低白蛋白血症以及血清转氨酶和碱性磷酸酶水平升高2至17倍。肝脏抗氧化酶、超氧化物歧化酶和过氧化氢酶分别下降 28% 和 60%。然而，肝脏脂质过氧化没有增加。这些研究表明，肝硬化肝细胞损伤可能是由于氧自由基的直接攻击造成的。人们普遍认为，肝脏中的脂质过氧化可能不是肝硬化发展的先决条件。
Liver cirrhosis was induced in rats by the combined action of oral phenobarbitone and inhalations of carbon tetrachloride vapors. These rats manifested hepatosplenomegaly, hypoalbuminemia, and 2- to 17-fold elevation in serum transaminases and alkaline phosphatase levels. The hepatic antioxidant enzymes, superoxide dismutase and catalase, showed 28 and 60% decreases, respectively. There was, however, no increase in the hepatic lipid peroxidation. These studies suggest that in cirrhosis liver cell damage may result due to the direct attack of the oxygen free radicals. Lipid peroxidation in the liver may not be a prerequisite for the development of cirrhosis, as is generally believed.