Bidirectional interactions between dietary curcumin and gut microbiota
Bidirectional interactions between dietary curcumin and gut microbiota
复制标题
DOI：
10.1080/10408398.2018.1478388
复制
发表时间：
2018-12
影响因子：
10.2
通讯作者：
Liang Shen;Hong-Fang Ji
中科院分区：
文献类型：
--
作者：
Liang Shen;Hong-Fang Ji
摘要姜黄素是一种具有悠久历史的多酚类化合物，作为草药、食用香料和食品着色剂。尽管姜黄素具有广泛的生物学和药理学活性，但其生物利用度极低，这使得其药理学非常有趣，也阻碍了其临床应用。近年来，有充分的证据支持肠道菌群的改变与许多疾病之间的联系。有趣的是，口服给药后，姜黄素显示出其在肠道中的优先分布和积累。鉴于上述方面，我们从两个角度综述了姜黄素与肠道微生物群之间双向相互作用的最新知识：（1）姜黄素对肠道微生物群的调节和（2）消化微生物群对姜黄素的生物转化。此外，该研究涉及3个潜在的药理学意义：（1）鉴定比母体姜黄素更具活性和生物利用度的代谢产物;（2）评估姜黄素的肠道微生物群调节对其药理作用的贡献;（3）鉴于其临床安全性，开发基于肠道微生物群调节的姜黄素疾病预防/治疗策略。这篇综述对于加深我们对姜黄素作用机制的理解，并为如何使用这种天然化合物来对抗人类疾病提供未来的方向是重要的。
Abstract Curcumin is a polyphenolic compound with a long history of use as an herbal remedy, dietary spice, and food-coloring agent. Despite curcumin possesses a wide range of biological and pharmacological activities, it exhibits extremely poor bioavailability, which makes its pharmacology intriguing and also hinders its clinical application. In recent years, there is ample evidence supporting the associations between the alteration of gut microbiota and many diseases. Interestingly, after oral administration, curcumin shows its preferential distribution and accumulation in the intestine. In view of the above aspects, we reviewed the updated knowledge regarding the bidirectional interactions between curcumin and gut microbiota from two perspectives: (1) gut microbiota regulation by curcumin and (2) curcumin biotransformation by digestive microbiota. Besides the study deals with 3 potential pharmacological implications: (1) identification of metabolites being more active and bioavaliable than parent curcumin; (2) assessment of contribution of gut microbiota regulation of curcumin to its pharmacological effects and (3) development of gut microbiota regulation-based disease prevention/treatment strategy for curcumin in view of its clinical safety. This review is important to deepen our understanding of the mechanisms of action of curcumin and to provide future directions about how to use this natural compound to combat human diseases.