The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man
The effect of 2 weeks vitamin C supplementation on immunoendocrine responses to 2.5 h cycling exercise in man
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DOI：
10.1007/s00421-006-0196-7
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发表时间：
2006-07-01
影响因子：
3
通讯作者：
Gleeson, M
中科院分区：
文献类型：
--
作者：
Davison, G;Gleeson, M
应激激素（下丘脑-垂体-肾上腺轴）和某些细胞因子的全身浓度增加可能导致长时间运动后通常观察到的免疫细胞功能抑制。本研究的目的是确定2周的补充维生素C（VC）对皮质醇，促肾上腺皮质激素，白细胞介素-6，氧化应激和中性粒细胞反应的影响，以一个单一的回合的耐力运动。9名接受过耐力训练的健康男性在补充安慰剂（PLA）或VC（1000 mg/天（-1））2周后，以60% VO 2 max运动2.5 h。所有参与者均使用随机交叉设计完成了两项试验，试验之间至少有14天的洗脱期。血浆皮质醇浓度存在显著的试验x时间相互作用效应（P = 0.039），其在VC试验中倾向于较低，但事后分析未发现试验间差异。与PLA试验相比，VC试验中的运动后嗜盐性显著降低（P < 0.014）。中性粒细胞功能指标（细菌刺激的弹性蛋白酶释放、fMLP或PMA刺激的氧化爆发）无试验x时间相互作用。然而，与PLA试验相比，VC中存在更高的fMLP刺激的中性粒细胞氧化爆发的趋势（试验x时间相互作用，P = 0.075）。这些结果表明，补充VC长达2周的时间几乎没有保护中性粒细胞功能的抑制，这通常发生在耐力运动后。
An increased systemic concentration of stress hormones (of the hypothalamic-pituitary adrenal axis) and some cytokines may contribute to the depression of immune cell function typically observed after prolonged exercise. The aim of the present study was to determine the effect of 2 weeks of supplementation with vitamin C (VC) on cortisol, adrenocorticotrophic hormone, interleukin-6, oxidative stress and neutrophil responses to a single bout of endurance exercise. Nine healthy endurance-trained males exercised for 2.5 h at 60% VO2max after two weeks of placebe (PLA) or VC (1000 mg day(-1)) supplementation. All participants completed both trials utilising a randomised crossover design with a minimum 14 day washout period between trials. There was a significant trial x time interaction effect for plasma cortisol concentration (P = 0.039) which tended to be lower in the VC trial but post hoc analysis found no specific between trial differences. There was a significantly lower post-exercise neutrophilia (P < 0.014) in the VC trial, compared with the PLA trial. There was no trial x time interaction for measures of neutrophil function (bacteria-stimulated elastase release, fMLP or PMA-stimulated oxidative burst). However, there was a trend for higher fMLP-stimulated neutrophil oxidative burst in the VC compared with PLA trial (trial x time interaction, P = 0.075). These results suggest that supplementation with VC for a period of up to 2 weeks provides little to no protection against the depression of neutrophil function which typically occurs after endurance exercise.