The effects of prolonged abstinence on the processing of smoking cues: an ERP study among smokers, ex-smokers and never-smokers
The effects of prolonged abstinence on the processing of smoking cues: an ERP study among smokers, ex-smokers and never-smokers
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DOI：
10.1177/0269881107078494
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发表时间：
2007-11-01
影响因子：
4.1
通讯作者：
Franken, Ingmar H. A.
中科院分区：
文献类型：
--
作者：
Littel, Marianne;Franken, Ingmar H. A.
加工偏差是药物滥用的一个重要特征。加工偏差是否是尼古丁成瘾的一个或多或少的永久性特征的问题仍有待解决。本研究探讨了吸烟状况对吸烟相关加工偏差的影响。我们采用事件相关脑电位（ERPs）作为测量加工偏差的工具来研究这一问题。此外，自我报告措施的尼古丁渴望和吸烟刺激的愉快评级。比较了吸烟者、戒烟者和从不吸烟者对与吸烟有关的图片和中性图片的脑电反应。本研究表明，无论是P300和SPW振幅在响应吸烟相关的图片显着增强吸烟者比戒烟者和从不吸烟者在额叶和中央网站，而响应中性图片的P300和SPW振幅的幅度没有显着差异的三组之间。因此，可以得出结论，吸烟者比戒烟者和吸烟者对吸烟相关图片表现出更多的偏见。由于戒烟者和从不吸烟者的P300和SPW振幅之间没有显著差异，因此也可以得出结论，戒烟者显示出与从不吸烟者相同（低）水平的加工偏差。此外，吸烟者对尼古丁的渴望程度和对吸烟刺激的愉悦程度高于戒烟者。可以得出结论，吸烟相关的渴望，愉快的评级，和加工偏差后，一段时间的长期禁欲。
Processing bias is an important feature of substance abuse. The issue whether processing bias is a more or less permanent feature of nicotine addiction remains to be resolved. The present study addresses the role of smoking status on smoking-related processing bias. We employed Event-Related Brain Potentials (ERPs) as measure of processing bias to investigate this issue. Further, self-report measures of nicotine craving and pleasantness ratings of smoking stimuli were obtained. Three groups, smokers, ex-smokers and never-smokers, were compared on their electrophysiological brain response to smoking-related and neutral pictures. The present study shows that both the P300 and SPW amplitudes in response to smoking-related pictures are significantly more enhanced for smokers than for ex-smokers and never-smokers at frontal and central sites, whereas the magnitude of the P300 and SPW amplitudes in response to neutral pictures does not differ between the three groups. Accordingly, it can be concluded that smokers show more bias for smoking-related pictures than ex-smokers and smokers. Because there is no significant difference between the P300 and SPW amplitudes of ex-smokers and never-smokers, it can also be concluded that ex-smokers display the same (low) level of processing bias as never-smokers. In addition, nicotine-craving ratings and pleasantness ratings of smoking stimuli were higher in smokers compared to ex-smokers. It can be concluded that the smoking-related craving, pleasantness rating, and processing bias decreases after a period of prolonged abstinence.