Titanium implant materials with improved riocompatibility through coating with phosphonate-anchored cyclic RGD peptides
Titanium implant materials with improved riocompatibility through coating with phosphonate-anchored cyclic RGD peptides
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DOI：
10.1002/cbic.200500031
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发表时间：
2005-11-01
期刊：
影响因子：
3.2
通讯作者：
Kessler, H
中科院分区：
文献类型：
--
作者：
Auernheimer, J;Zukowski, D;Kessler, H
改善植入物骨整合的一个关键点是通过特别有利于成骨细胞的粘附来使其具有骨促进作用。模拟 I 成骨细胞与细胞外基质的生理粘附过程可改善体外细胞粘附，并导致体内植入物的改善和早期骨整合。我们的方法包括用定制的环状RGD肽涂覆钛植入物，从而使它们能够通过多聚磷酸盐与细胞表面上的特定整合素受体结合。介绍了这种非常稳定的新型锚固在实际应用中的优点。
One key point for improving osseous integration of implants is to render them osteopromotive by specifically favoring the adhesion of osteoblasts. Mimicking the physiological adhesion process of I osteoblasts to the extracellular matrix improves cell adhesion in vitro and results in improved and earlier osseous integration of implants in vivo. Our approach involves coating titanium implants with a tailor-made cyclic-RGD peptide, thus allowing them to bind to specific integrin receptors on the cell surface through multimeric phosphonates. The advantages of this very stable, new type of anchoring for practical application are presented.