Short-term effect of pollen exposure on antiallergic drug consumption
Short-term effect of pollen exposure on antiallergic drug consumption
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DOI：
10.1016/s1081-1206(10)60657-6
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发表时间：
2007-09-01
影响因子：
5.9
通讯作者：
Caillaud, Denis
中科院分区：
文献类型：
--
作者：
Fuhrman, Claire;Sarter, Helene;Caillaud, Denis
背景：已有几项研究调查了花粉暴露与哮喘急诊入院的关系，但只有2项研究调查了空气传播变应原对鼻炎或结膜炎会诊的影响，没有一项研究将药物消耗作为健康指标。目的：考虑到空气污染和气象因素的潜在混杂影响，分析法国克莱蒙费朗市区花粉暴露与抗过敏药物消耗之间的短期关联。方法：我们使用法国健康保险数据库，从2000年1月1日至2001年12月31日，以及2003年1月1日，从克莱蒙费朗市区选择所有受益于抗过敏治疗报销的个人一直到2004年12月31日。治疗过敏性鼻炎、鼻窦炎或结膜炎(ARC)的发作被定义为同一处方上口服抗组胺药和局部抗过敏药物的相关性。用Poisson回归模型分析了花粉浓度日变化与处理ARC病例数日变化之间的关系。结果：Poaceae植物发生ARC的风险显著增加(5%，P
Background: Several studies have investigated the association between pollen exposure and asthma emergency admissions, but only 2 have investigated the effect of airborne allergens on consultations for rhinitis or conjunctivitis and none has used drug consumption as the health indicator.Objective: To analyze the short-term association between pollen exposure and antiallergic drug consumption in the urban area of Clermont-Ferrand, France, taking into account the potentially confounding effect of air pollution and meteorological factors.Methods: We used the French health insurance database to select all individuals from the Clermont-Ferrand urban area having benefited from reimbursement for antiallergic treatment from January 1, 2000, through December 31, 2001, and from January 1, 2003, through December 31, 2004. An episode of treated allergic rhinitis, rhinosinusitus, or conjunctivitis (ARC) was defined as the association of an oral antihistamine and a local antiallergic drug on the same prescription. The relations between daily changes in pollen concentrations and daily changes in the number of treated ARC cases were analyzed using a Poisson regression model with penalized spline functions.Results: The risk of treated ARC associated with an interquartile increase in pollen concentration increased significantly for Poaceae (5%, P