Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518A>G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis
Association of Monocyte Chemoattractant Protein-1 (MCP-1)-2518A>G Polymorphism with Susceptibility to Coronary Artery Disease: A Meta-Analysis
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DOI：
10.1111/ahg.12105
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发表时间：
2015-05-01
影响因子：
1.9
通讯作者：
Wu, Huijian
中科院分区：
文献类型：
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作者：
Bai, Xiao-Yan;Li, Shujing;Wu, Huijian
我们试图系统地阐明单核细胞趋化蛋白-1（MCP-1）-2518A>G多态性与冠心病（CAD）风险之间的关系。通过PubMed、EBSCO和Web of Science数据库确定符合条件的研究。估计MCP-1多态性对CAD的影响程度及其可能的作用方式。在特定的遗传模型中合并比值比（OR）和95%置信区间（CI），以评估相关性。共纳入21项研究。总体人群中CAD风险存在显著的基因效应（似然比检验：p < 0.0001）。GG和AG基因型患者发生冠心病的危险性分别是AA基因型患者的1.435倍（95% CI：1.183-1.740）和1.087倍（95% CI：1.008-1.172）。这些基因效应表明隐性模型是合适的。在隐性模型中，合并OR为1.362（95% CI：1.137-1.631; p（未校正）= 0.001，p（FDR）= 0.005）。在种族分层分析中，在高加索人群中观察到显著相关性（OR = 1.492; 95% CI：1.106-2.014; p（未校正）= 0.009，p（FDR）= 0.015），而在亚洲人群中未检测到统计学显著相关性（校正后p = 0.124）。结果提示MCP-1 - 2518 A>G多态性可能与冠心病易感性相关，尤其在白种人中。
We attempted to systematically elucidate the association between monocyte chemoattractant protein-1 (MCP-1) -2518A>G polymorphism and risk of coronary artery disease (CAD). Eligible studies were identified through PubMed, EBSCO, and Web of Science Databases. The magnitude of MCP-1 polymorphism effect and its possible mode of action on CAD were estimated. The odds ratio (OR) with 95% confidence intervals (CI) were pooled in a specific genetic model to assess the association. A total of 21 studies were involved. There was significant gene effect on CAD risk in the overall population (likelihood ratio test: p < 0.0001). Patients with GG and AG genotypes had 1.435 (95% CI: 1.183-1.740) and 1.087 (95% CI: 1.008-1.172) times higher risk of CAD than those with AA genotype. These gene effects suggested a recessive model to be appropriate. The pooled OR was 1.362 (95% CI: 1.137-1.631; p(uncorrected) = 0.001, p(FDR) = 0.005) in the recessive model. In the ethnicity-stratified analysis, significant association was observed in the Caucasian population (OR = 1.492; 95% CI: 1.106-2.014; p(uncorrected) = 0.009, p(FDR) = 0.015), whereas no statistical significant association was detected in the Asian population (adjusted p = 0.124). The results suggested that MCP-1 -2518A>G polymorphism may be associated with susceptibility to CAD, especially in Caucasians.