The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy
The reproducibility and sensitivity of sural nerve morphometry in the assessment of diabetic peripheral polyneuropathy
复制标题
腓肠神经形态测定法评估糖尿病周围多发性神经病的重现性和敏感性
作者：
A. Sima;Morton B. Brown;A. Prashar;S. Chakrabarti;C. Laudadio;D. Greene
通过腓肠神经活检的形态计量学分析，研究了糖尿病周围神经病变的神经纤维丢失、萎缩和损伤及其对代谢干预的反应。这些形态测量中个体内和个体间变异的幅度和来源以前尚未以系统的方式进行过研究。神经纤维损伤的形态测量参数进行了测量，在四个独立的束从双侧腓肠神经标本获得死后从13个糖尿病和13个非糖尿病受试者。计算个体内和个体间变异系数，并与正常人和糖尿病受试者之间的差异幅度进行比较。几个形态学变量出现了高度敏感和可重复的措施，神经纤维损伤的糖尿病周围多发性神经病的临床研究。这些观察结果提供了一个合理的基础，设计未来的临床试验采用形态学终点。
SummaryThe nerve fibre loss, atrophy and injury of diabetic peripheral polyneuropathy and their responses to metabolic intervention have been studied by morphometric analysis of sural nerve biopsies. The magnitudes and sources of intra- and inter-individual variation in these morphometric measures have not been investigated previously in a systematic manner. Morphometric parameters of nerve fibre damage were measured in four separate fascicles from bilateral sural nerve specimens obtained post-mortem from 13 diabetic and 13 non-diabetic subjects. Intra- and inter-individual coefficients of variation were computed and compared to the magnitude of the differences between normal and diabetic subjects. Several morphometric variables emerged as highly sensitive and reproducible measures of nerve fibre damage suitable for clinical studies of diabetic peripheral polyneuropathy. These observations provide a rational basis for the design of future clinical trials employing morphometric end-points.
非胰岛素依赖型糖尿病受试者的血糖控制和神经传导异常。
影响因子：
39.2
作者：
Graf,RJ;Halter,JB;Pfeifer,MA;Halar,E;Brozovich,F;PorteJr,D
通讯作者：
PorteJr,D
影响因子：
158.5
作者：
SIMA, AAF;BRIL, V;GREENE, DA
通讯作者：
GREENE, DA