Altered self-referential network in resting-state amnestic type mild cognitive impairment
Altered self-referential network in resting-state amnestic type mild cognitive impairment
复制标题
静息态遗忘型轻度认知障碍中自我参照网络的改变
DOI：
10.1016/j.cortex.2011.02.011
复制
发表时间：
2012-05-01
期刊：
影响因子：
3.6
通讯作者：
Zhang, Zhijun
中科院分区：
文献类型：
--
作者：
Bai, Feng;Shi, Yongmei;Zhang, Zhijun
自我参照能力受损已经在被认为可能发展为临床阿尔茨海默病（AD）的遗忘性轻度认知障碍（aMCI）受试者中观察到。自我参考网络（SRN）模式的改变在aMCI被试尤其是静息状态下尚不清楚，而SRN与aMCI其他静息状态网络之间的关系尚不清楚。方法：对26例aMCI患者和18例匹配的健康对照进行静息状态功能磁共振成像（fMRI）纵向扫描。采用独立成分分析分离SRN，并进一步采用互相关方法探讨SRN与其他静息状态网络之间的关系。结果：与对照组相比，选择性SRN的变化与aMCI中腹内侧前额叶皮层/眶内侧前额叶皮层/直回之间的功能连接增加以及基线时SRN的平均时间序列有关，而这些功能连接在同一受试者随访后与更大程度的纵向减少有关。此外，在aMCI受试者中，SRN与默认模式网络之间的连通性下降关系更大。结论：我们首次在aMCI受试者中发现了静息状态SRN模式的改变，这有助于指导后续研究，以明确SRN在aMCI进展中的确切功能意义。爱思唯尔有限公司2011年版权所有。版权所有。
Introduction: Impaired capacity for self-reference has been observed in amnestic mild cognitive impairment (aMCI) subjects who are thought to be the likely to develop into clinical Alzheimer's disease (AD). The altered pattern of self-referencing network (SRN) is not yet well understood in aMCI subjects particularly in resting state, and little is known about the relationship between SRN and other resting-state networks in aMCI subjects.Methods: The study was designed to administer longitudinal resting-state functional magnetic resonance imaging (fMRI) scanning to 26 aMCI subjects and 18 matched healthy controls. Independent component analysis was used to separate SRN, and a further crosscorrelation approach was recruited to explore the relationship between SRN and other resting-state networks.Results: Compared to controls, selective changes of SRN regarding to the increased functional connectivity between ventromedial prefrontal cortex/medial orbital prefrontal cortex/gyrus rectus and the mean time series of SRN at baseline in aMCI, while these functional connections were associated with more extent of longitudinal diminish after follow up in the same subjects. In addition, greater decreased connectivity relationship between SRN and default mode network was observed in aMCI subjects.Conclusions: Altered patterns of resting-state SRN were firstly explored in aMCI subjects, and it could help guide subsequent investigations designed to specify the precise functional implications of SRN in the progression of aMCI. Crown Copyright (C) 2011 Published by Elsevier Srl. All rights reserved.