The role of IL-2 and soluble IL-2R in depression and antidepressant response.
The role of IL-2 and soluble IL-2R in depression and antidepressant response.
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发表时间：
2009-07
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通讯作者：
T. Eller;V. Vasar;J. Shlik;E. Maron
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作者：
T. Eller;V. Vasar;J. Shlik;E. Maron
细胞因子在抑郁症的发病机制和治疗中被广泛研究。本文综述了IL-2和可溶性IL-2R在抑郁症中的潜在重要性，以及它们在抗抑郁治疗效果中的中介作用。总体而言，在观察到的细胞因子浓度或其变化与重度抑郁症的临床指标之间的关联中并没有一致的模式。一个耐人寻味的问题是，免疫系统标志物的预处理水平，如IL-2Rα，是否可以用来预测抗抑郁治疗的反应。根据目前可用的数据，这个问题仍然没有得到解决。这篇综述还强调了在抑郁症背景下与IL-2和IL-2R测量有关的某些方法学问题，并为该领域的进一步研究提供了思路。
Cytokines are widely studied in the context of the pathogenesis and treatment of major depression. This review focuses on the potential importance of IL-2 and soluble IL-2R in major depression, as well as on their role in the mediation of the effects of antidepressant treatment. In general, there has been no consistent pattern in the associations observed between cytokine concentration, or changes thereof, and clinical indices of major depression. One intriguing question is whether pretreatment levels of immune system markers, such as IL-2R alpha, can be used to predict responses to antidepressant treatment. Based on the currently available data, this issue remains unresolved. This review also highlights certain methodological problems pertaining to the measurement of IL-2 and IL-2R in the context of depression and presents ideas for further research in this field.