Changes in murine resistance to Listeria monocytogenes infection induced by amphotericin B.
Changes in murine resistance to Listeria monocytogenes infection induced by amphotericin B.
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两性霉素 B 诱导小鼠对单核细胞增生李斯特氏菌感染的抵抗力变化。
DOI：
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发表时间：
1973
影响因子：
6.4
通讯作者：
G. Kobayashi
中科院分区：
文献类型：
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作者：
M. Z. Thomas;G. Medoff;G. Kobayashi
在感染单核细胞增生李斯特菌前24小时给小鼠注射阿替霉素B可刺激宿主产生耐药性。相反，在感染L.单核细胞增多症与未处理动物的细胞相比，在处死前24小时静脉注射多烯的小鼠的腹膜渗出液细胞中观察到杀微生物活性增加。在体外培养正常小鼠腹腔渗出液细胞与阿替霉素B导致杀微生物活性下降。两性霉素B对L.单核细胞增多症
Injection of amphotericin B into mice 24 hr before infection with Listeria monocytogenes stimulated host resistance. In contrast, host resistance was decreased when the antibiotic was injected after infection with L. monocytogenes. In comparison with cells from untreated animals, increased microbicidal activity was observed in peritoneal exudate cells of mice injected iv with the polyene 24 hr before sacrifice. In-vitro incubation of normal murine peritoneal exudate cells with amphotericin B resulted in decreased microbicidal activity. Amphotericin B had no in-vitro effect on the viability of L. monocytogenes.