Increased secretion of amylin in women with polycystic ovary syndrome
Increased secretion of amylin in women with polycystic ovary syndrome
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DOI：
10.1016/j.fertnstert.2009.02.086
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发表时间：
2010-06-01
影响因子：
6.7
通讯作者：
Nagamani, Manubai
中科院分区：
文献类型：
--
作者：
James, Summer;Moralez, Jennifer;Nagamani, Manubai
目的：调查多囊卵巢综合征 (PCOS) 女性的胰淀素分泌情况。设计：前瞻性病例对照研究。地点：学术机构。患者：20 名患有 PCOS 的女性和 10 名具有排卵周期且体重指数相匹配的女性。干预措施：进行口服葡萄糖耐量试验，并在空腹时和摄入葡萄糖后测量葡萄糖、胰岛素和胰淀素水平。计算胰岛素、胰岛淀粉样多肽和葡萄糖的曲线下面积。 10 名患有 PCOS 的女性接受了二甲双胍治疗，10 名女性接受了罗格列酮治疗，为期 6 个月。在治疗前后测量胰淀素水平。结果：多囊卵巢综合征女性的空腹胰淀素水平和对口服葡萄糖的胰淀素反应显着增加。禁食时，多囊卵巢综合症女性和对照组的胰岛素和胰岛淀粉样多肽水平之间存在显着的正相关性。摄入葡萄糖后，胰岛淀粉样多肽反应与多囊卵巢综合症女性的葡萄糖反应相关。二甲双胍治疗会降低胰淀素水平，但罗格列酮治疗不会降低。结论：在患有 PCOS 的女性中，[1] 胰淀素分泌增加，[2] 空腹状态下，胰岛素和胰淀素分泌受到共同调节，[3] 摄入葡萄糖后，葡萄糖水平调节胰淀素释放，[4] 胰岛素增敏剂二甲双胍（而非罗格列酮）减少胰淀素分泌。 （Fertil Steril (R) 2010；94: 211-5。(C) 2010，美国生殖医学会。）
Objective: To investigate amylin secretion in women with polycystic ovary syndrome (PCOS).Design: Prospective, case-control study.Setting: Academic institution.Patient(s): Twenty women with PCOS and 10 with ovulatory cycles who matched for body mass index.Intervention(s): An oral glucose tolerance test was performed, and glucose, insulin, and amylin levels were measured at fasting and after glucose ingestion. The area under the curve for insulin, amylin, and glucose was calculated. Ten women with PCOS were treated with metformin and 10 women with rosiglitazone for 6 months. Amylin levels were measured before and after treatment.Result(s): Fasting amylin levels and amylin response to oral glucose were significantly increased in women with PCOS. At fasting, there was significant positive correlation between insulin and amylin levels both in women with PCOS and control subjects. After glucose ingestion, amylin response correlated with the glucose response in women with PCOS. Amylin levels decreased with metformin but not with rosiglitazone treatment.Conclusion(s): In women with PCOS, [1] there is increased secretion of amylin, [2] insulin and amylin secretion is coregulated in the fasting state, [3] after glucose ingestion, glucose levels regulate amylin release, and [4] the insulin-sensitizing agent metformin, but not rosiglitazone, reduces amylin secretion. (Fertil Steril (R) 2010; 94: 211-5. (C) 2010 by American Society for Reproductive Medicine.)