Macrophages and age-dependent resistance to Herpes simplex virus in mice.
Macrophages and age-dependent resistance to Herpes simplex virus in mice.
复制标题
小鼠巨噬细胞和年龄依赖性单纯疱疹病毒抵抗力。
DOI：
10.4049/jimmunol.104.5.1160
复制
发表时间：
1970
影响因子：
4.4
通讯作者：
A. Allison
中科院分区：
文献类型：
--
作者：
M. Hirsch;B. Zisman;A. Allison
Peritoneal macrophages transferred from adult CBA mice protected suckling syngeneic mice from intraperitoneal infection with herpes simplex virus. Macrophages from adult mice stimulated with proteose-peptone solution were more effective in providing protection than were unstimulated macrophages. The enhanced resistance provided by stimulated macrophages was associated with more efficient phagocytosis and intracellular destruction of virus, and with greater production of interferon.
In contrast to the effects of stimulation on the adult mouse, the suckling mouse did not respond to proteose-peptone inoculation with the production of a population of macrophages that ingested more virus, produced more interferon, or more effectively destroyed virus.
