The role of assembly in insulin's biosynthesis
The role of assembly in insulin's biosynthesis
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DOI：
10.1016/s0959-440x(98)80037-7
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发表时间：
1998-04-01
影响因子：
6.8
通讯作者：
Steiner, D
中科院分区：
文献类型：
--
作者：
Dodson, G;Steiner, D
胰岛素是作为一种单链前体——前胰岛素原合成的，它包含一个N端信号序列以及一个连接胰岛素分子A链和B链的连接肽。新生的胰岛素原被引导进入受调控的分泌途径，转化为胰岛素并以微晶形式储存。这些过程利用了组装成含锌六聚体的形式。结构、化学和遗传学研究，以及对转基因动物和转染细胞的实验，正在为胰岛素生物合成中的分子事件提供新的细节。
Insulin is synthesised as a single-chain precursor, preproinsulin, that contains an N-terminal signal sequence and a connecting peptide linking the A and B chains of the insulin molecule. Nascent proinsulin is directed into the regulated secretory pathway, converted to insulin and stored as microcrystals. These processes exploit assembly to the zinc-containing hexamer. Structural, chemical and genetic studies, and experiments with transgenic animals and transfected cells, are providing new details about the molecular events in insulin's biosynthesis.