EFFECT OF STRAIN DIFFERENCES ON THE POTENCY TESTING OF RABIES VACCINES IN MICE
EFFECT OF STRAIN DIFFERENCES ON THE POTENCY TESTING OF RABIES VACCINES IN MICE
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DOI：
10.1016/0092-1157(89)90018-8
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发表时间：
1989-01-01
期刊：
影响因子：
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通讯作者：
BRUCKNER, L
中科院分区：
文献类型：
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作者：
BLANCOU, J;AUBERT, MFA;BRUCKNER, L
在交叉攻毒实验或交叉中和试验中，研究了几种狂犬病病毒株（即CVS、SAD和Flury（LEP）株）之间的抗原差异，这些病毒株是对用含有每种毒株的疫苗免疫的小鼠血清进行的。还包括一种典型的野生狐狸病毒株作为攻毒病毒。在兽用狂犬病疫苗的欧洲药典小鼠保护试验中，菌株差异影响了三种疫苗的相对效力，因为当疫苗株与攻毒病毒同源时，获得了较高的抗原值。通过小鼠中和抗体诱导证实了这一观察结果。
Antigenic differences between several strains of rabies virus, namely CVS, SAD and Flury (LEP) strains, were studied in cross-challenge experiments or cross-neutralization tests performed on sera of mice immunized with vaccines containing each strain. A typical wild fox virus strain was also included as challenge virus. The strain differences affected the relative potencies of the three vaccines in the European Pharmacopoeia mouse protection test for veterinary rabies vaccines, in that higher antigenic values were obtained when the vaccine strain was homologous to the challenge virus. This observation was confirmed by neutralizing antibody induction in mice.