An overview of structural genomics
An overview of structural genomics
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DOI：
10.1038/80697
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发表时间：
2000-11-01
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影响因子：
--
通讯作者：
Burley, SK
中科院分区：
文献类型：
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作者：
Burley, SK
随着对整个人类基因组序列以及各种模式生物和许多重要微生物病原体的序列的访问，结构生物学正处于戏剧性转变的边缘。我们新发现的丰富序列信息将作为结构基因组学重要倡议的基础。我们准备着手进行一项高通量X射线晶体学和NMR光谱学的系统计划，旨在开发蛋白质结构宇宙的全面视图。结构基因组学将产生大量的实验蛋白质结构（数万）和更多的计算比较蛋白质结构模型（数百万）。这一庞大的结构数据将免费提供，并有望加速生物科学所有领域的科学发现，包括自然生态系统的生物多样性和进化、农业植物遗传学、农场和家畜育种以及人类健康和疾病。
With access to sequences of entire human genomes plus those of various model organisms and many important microbial pathogens, structural biology is on the verge of a dramatic transformation. our newfound wealth of sequence information will serve as the foundation for an important initiative in structural genomics. We are poised to embark on a systematic program of high-throughput X-ray crystallography and NMR spectroscopy aimed at developing a comprehensive view of the protein structure universe. Structural genomics will yield a large number of experimental protein structures (tens of thousands) and an even larger number of calculated comparative protein structure models (millions). This enormous body of structural data will be freely available, and promises to accelerate scientific discovery in all areas of biological science, including biodiversity and evolution in natural ecosystems, agricultural plant genetics, breeding of farm and domestic animals, and human health and disease.