ANTIGENS INDUCED ON ERYTHROCYTES BY PLASMODIUM-FALCIPARUM - EXPRESSION OF DIVERSE AND CONSERVED DETERMINANTS
ANTIGENS INDUCED ON ERYTHROCYTES BY PLASMODIUM-FALCIPARUM - EXPRESSION OF DIVERSE AND CONSERVED DETERMINANTS
复制标题
DOI：
10.1126/science.2417315
复制
发表时间：
1986-01-10
期刊：
影响因子：
56.9
通讯作者：
HOWARD, RJ
中科院分区：
文献类型：
--
作者：
MARSH, K;HOWARD, RJ
感染了疟原虫的红细胞在其表面表达新的抗原。在对冈比亚自然感染儿童红细胞中的这些抗原进行的一项研究中，抗体介导的凝集试验显示了极端程度的抗原多样性。10名处于疟疾感染恢复期的儿童的血清样本与同一儿童的感染细胞发生反应，但通常不与其他儿童的感染细胞发生反应。冈比亚儿童的红细胞也表达了共同的决定因素：冈比亚成年人的血清经常与所有儿童的感染细胞表面反应，并通过吸收和洗脱实验显示含有识别几种分离株的抗体。暴露于受感染红细胞上的保守决定簇可能对自然或通过疫苗接种产生抗疟免疫力很重要。
Red blood cells that are infected with the malaria parasite Plasmodium falciparum express new antigens on their surface. In a study of these antigens in the erythrocytes of naturally infected children in the Gambia, an antibody-mediated agglutination assay revealed an extreme degree of antigenic diversity. Serum samples from each of ten children in the covalescent stage of malaria infection reacted with infected cells from the same child but generally not with infected cells from the other children. The Gambian children''s erythrocytes also expressed shared determinants: sera from Gambian adults often reacted with the surface of infected cells from all of the children and were shown by absorption and elution experiments to contain antibodies that recognized several isolates. Conserved determinants exposed on infected erythrocytes may be important for development of antimalarial immunity either naturally or through vaccination.