Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population.
Serum IGFBP7 levels associate with insulin resistance and the risk of metabolic syndrome in a Chinese population.
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中国人群血清 IGFBP7 水平与胰岛素抵抗和代谢综合征风险相关
DOI：
10.1038/srep10227
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发表时间：
2015-05-18
影响因子：
4.6
通讯作者：
Lai M
中科院分区：
文献类型：
--
作者：
Liu Y;Wu M;Ling J;Cai L;Zhang D;Gu HF;Wang H;Zhu Y;Lai M
代谢综合征（MetS）是主要的公共卫生问题之一，被视为常见慢性病发病的“共同土壤”，可能增加2型糖尿病的风险。 MetS 的主要潜在机制是胰岛素抵抗 (IR)。此外，之前的研究表明IGFBP7与胰岛素具有高亲和力，可能诱发IR。本研究的目的是首先通过相对较大的样本和基于人群的设计来评估血清 IGFBP7 水平与 IR 和 MetS 的关联。在一项基于人群的 MetS 病例对照研究中，HOMA-IR 用于评估胰岛素敏感性，并通过化学发光联免疫分析法测定血清 IGFBP7 水平。结果，MetS 和 IR 受试者的 IGFBP7 血清水平高于对照健康受试者。高血清 IGFBP7 水平会增加 MetS 和 IR 的风险。还发现血清 IGFBP7 水平与腰臀比 (WHR)、HDL 和 LDL 等代谢相关参数显着相关。这些发现表明血清 IGFBP7 水平与 IR 和 MetS 相关，为 IR 和 MetS 的机制提供了新的见解。 IGFBP7 可能是 IR 和 Mets 的潜在干预靶点。
Metabolic syndrome (MetS), one of the major public health concerns, is regarded as the “common soil” of incidence of common chronic diseases and may increase the risk of type 2 diabetes. The predominant underlying mechanism of MetS is insulin resistance (IR). Additionally, previous studies have indicated that IGFBP7 has high affinity of binding with insulin and might induce IR. The objective of this study was to firstly evaluate the associations of serum IGFBP7 levels with IR and MetS with a relatively large sample and population based design. In a population based MetS case-control study, HOMA-IR was used to evaluate the insulin sensitivity and serum IGFBP7 levels were determined with chemiluminescence–linked immunoassay. As a result, the subjects of MetS and IR had higher serum levels of IGFBP7 than control healthy subjects. High serum IGFBP7 levels increased the risk of MetS and IR. Serum IGFBP7 levels were also found to be significantly correlated with metabolic-associated parameters of Waist-to-hip ratio (WHR), HDL and LDL. These findings suggest that serum IGFBP7 levels are associated with IR and MetS, providing new insight into the mechanism of IR and Mets. IGFBP7 may be a potential interventional target for IR and Mets.