High-fat diet-induced obesity is attenuated by probiotic strain Lactobacillus paracasei ST11 (NCC2461) in rats
High-fat diet-induced obesity is attenuated by probiotic strain Lactobacillus paracasei ST11 (NCC2461) in rats
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DOI：
10.1016/j.orcp.2008.04.003
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发表时间：
2008-09-01
影响因子：
4.3
通讯作者：
Nagai, Katsuya
中科院分区：
文献类型：
--
作者：
Tanida, Mamoru;Shen, Jiao;Nagai, Katsuya
最近的研究表明，益生菌乳酸菌能够影响植物神经活动，调节血糖和心血管功能。在这里介绍的研究中，我们发现长期摄入副干酪乳杆菌ST 11（NCC 2461）可以降低体重和腹部脂肪重量。为了研究自主神经在NCC 2461抗肥胖作用中的可能作用，我们检测了十二指肠内（ID）注射NCC 2461菌株L。paracasei ST 11（NCC 2461）对麻醉大鼠中支配白色脂肪组织（WAT-SNA）的交感神经活动的影响，并且发现其加速了WAT-SNA。此外，十二指肠内（ID）注射NCC 2461增加了支配棕色脂肪组织（BAT-SNA）的交感神经活动，并降低了肝迷走神经活动（HVNA）。此外，使用清醒大鼠，我们检查了胃内（IG）注射NCC 2461对脂解和BAT产热的影响，并观察到其明显升高血浆FFA水平、BAT温度和腹部温度。因此，这些数据表明NCC 2461影响自主神经，增强脂解，并降低大鼠体重。(c)2008年亚洲大洋洲肥胖研究协会。由Elsevier Ltd.出版，保留所有权利。
In a recent study, we obtained some evidences that probiotic strain Lactobacillus affects the autonomic nerve activities and regulates blood glucose and cardiovascular function. In the study presented here, we found that long-term ingestion of the lactobacillus strain Lactobacillus paracasei ST11 (NCC2461) reduced body weight and abdominal fat weight. To investigate possible role of autonomic nerves in anti-obesity action of NCC2461, we examined the effects of intraduodenal (ID) injection of the lactobacillus strain L. paracasei ST11 (NCC2461) on sympathetic nerve activity innervating white adipose tissue (WAT-SNA) in urethane-anesthetized rats, and found that it accelerated WAT-SNA. Moreover, intraduodenal (ID) injection of NCC2461 increased in sympathetic nerve activity innervating brown adipose tissue (BAT-SNA) and decreased in hepatic vagal nerve activity (HVNA). In addition, using conscious rats, we examined the effects of intra-gastric (IG) injection of NCC2461 on lipolysis and BAT thermogenesis, and observed that it clearly elevated the plasma FFA level, BAT temperature and abdominal temperature. Thus, these data suggest that the NCC2461 affects autonomic nerves, enhances lipolysis, and reduces body weight in rats. (c) 2008 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. Alt rights reserved.