Validation of the Chinese translated version of ISAAC core questions for atopic eczema
Validation of the Chinese translated version of ISAAC core questions for atopic eczema
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DOI：
10.1046/j.1365-2222.2001.01089.x
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发表时间：
2001-06-01
影响因子：
6.1
通讯作者：
Lai, CKW
中科院分区：
文献类型：
--
作者：
Chan, HH;Pei, A;Lai, CKW
国际儿童哮喘和过敏研究（ISAAC）旨在对儿童特应性疾病的流行病学数据进行国际比较。这样做将获得进一步的病因学信息，从而为今后的研究提供一个框架。全球ISAAC关于特应性皮炎患病率的结果表明，不同国家记录的差异为60倍。这种程度的差异可能部分是由于翻译的问卷，并没有在所有参与countries.Objective验证中文版的ISAAC核心问题的特应性湿疹。以皮肤科医生的临床检查为金标准，我们验证了中文版的特应性湿疹ISAAC核心问题。结果本研究所测得的Youden指数明显低于英国的Youden指数，且与英国的Youden指数有显著性差异（P <0.05）。结论中文问卷对特应性湿疹患病率的评估效果不如英文问卷，中文问卷的敏感度为23.5%~ 70.6%。先前研究报告的中国人群中特应性湿疹患病率较低的迹象至少部分是由于翻译问卷的问题。
Background The International Study of Asthma and Allergies in Childhood (ISAAC) was designed to allow international comparison of epidemiological data on atopic conditions in childhood. In so doing, further aetiological information would be obtained that in turn would provide a framework for future studies. The global ISAAC results on the prevalence of atopic dermatitis indicated a 60-fold variation recorded in different countries. Such a degree of difference may be partially due to the translated questionnaires that were not validated in all of the involved countries.Objective To validate the Chinese version of the ISAAC core questions for atopic eczema.Methods One thousand nine hundred and twenty children aged between 3 and 5 were randomly recruited from 13 kindergartens in Hong Kong. Using a dermatologist's clinical examination as the gold standard, we validated the Chinese version of the ISAAC core questions for atopic eczema. The Youden's Indexes obtained in our study were compared with those obtained in the United Kingdom's validation study.Results The Youden's Indexes obtained in our study were significantly tower than those from the United Kingdom. The low scores were likely to be due to a reduction in the sensitivity of the Chinese questionnaire, which ranged from 23.5% to 70.6%.Conclusion Our findings indicate that the translated questionnaire is less effective than the English version in assessing the prevalence of atopic eczema. The indication of a low prevalence of atopic eczema among the Chinese population reported in previous studies was at least partially due to problems with the translated questionnaire.