Self-compassion and neural activity during self-appraisals in depressed and healthy adolescents.
Self-compassion and neural activity during self-appraisals in depressed and healthy adolescents.
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DOI：
10.1016/j.jad.2023.07.012
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发表时间：
2023-07
影响因子：
6.6
通讯作者：
Guanmin Liu;Carmen Santana-Gonzalez;T. Zeffiro;Na Zhang;Maggie Engstrom;Karina M Quevedo
中科院分区：
文献类型：
--
作者：
Guanmin Liu;Carmen Santana-Gonzalez;T. Zeffiro;Na Zhang;Maggie Engstrom;Karina M Quevedo
背景抑郁症是青少年最受关注的精神障碍之一。由于自我参照处理过程中的非典型过度神经活动通常与抑郁症有关，因此确定与自我参照处理过程中较低的抑郁症和较少的过度神经活动相关的心理因素对于治疗开发至关重要。本研究探讨了自我同情--青少年抑郁症的保护因素--与自我评价过程中神经活动的关系，以及它们与抑郁症和健康青少年抑郁症严重程度的关系。（79例符合抑郁症临床诊断; 36例为匹配的健康对照），年龄11 - 17岁（68例女性）。自我同情和抑郁的严重程度进行了测量与自我报告量表。在扫描仪中，参与者被要求判断是否他们听到的短语描述他们从四个角度（自我，母亲，同学，和最好的朋友）。结果更高的自我同情与较低的PCC/楔前叶活动，特别是在负价自我评价，并解释其与抑郁症的严重程度降低。在抑郁青年中，较高的自我同情与较低的上级颞回/鳃盖/中央后回/颞叶活动相关，特别是在积极评价自我评价时。在健康的青年，更高的自我同情与更高的活动在这些regions.ConclusionsSelf-compassion与较少过度的经验沉浸和/或自传体记忆检索在负面的自我评价。针对PCC/楔前叶活动的神经刺激干预，结合针对自我同情的行为干预，可能是一个有前途的方法来治疗青年抑郁症。
BackgroundDepression is one of the most concerning mental disorders in youth. Because atypical excessive neural activity during self-referential processing is often implicated in depression, identifying psychological factors that link to lower depression and less excessive neural activity during self-referential processing is critical for treatment development. This study examined the relationship between self-compassion – a protective factor of youth depression – and neural activity during self-appraisals, a well-established experimental paradigm for studying self-referential processing, and their associations with depression severity in depressed and healthy youth.MethodsThe sample consisted of 115 youth (79 met the clinical diagnosis of depression; 36 were matched healthy controls) aged from 11 to 17 years (68 females). Self-compassion and depression severity were measured with self-reported scales. In the scanner, participants were asked to judge whether the phrases they heard described them from four perspectives (self, mother, classmate, and best friend).ResultsHigher self-compassion was associated with lower PCC/precuneus activity especially during negatively-valenced self-appraisals and explained its association with reduced depression severity. In depressed youth, higher self-compassion was associated with lower superior temporal gyrus/operculum/postcentral gyrus/insula activity especially during positively-valenced self-appraisals. In healthy youth, higher self-compassion was associated with higher activity in these regions.ConclusionsSelf-compassion was associated with less excessive experiential immersion and/or autobiographical memory retrieval during negative self-appraisals. Neural stimulation interventions targeting PCC/precuneus activity during negative self-appraisals combined with behavioral interventions targeting self-compassion could be a promising approach to youth depression treatment.