Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019.
Deciphering the contributions of neuroinflammation to neurodegeneration: lessons from antibody-mediated encephalitis and coronavirus disease 2019.
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DOI：
10.1097/wco.0000000000001033
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发表时间：
2022-04-01
影响因子：
4.8
通讯作者：
Day GS
中科院分区：
文献类型：
--
作者：
Shir D;Day GS
神经炎症会促进神经变性吗？神经变性会促进神经炎症吗？或者这两个问题的答案都是肯定的？这些问题在患有典型的年龄相关性神经退行性疾病的患者中被证明具有挑战性，这些患者的神经炎症和神经退行性疾病的发作在很大程度上是未知的。从与急性神经炎症相关的疾病中恢复的患者，包括罕见形式的抗体介导的脑炎（AME）和2019年新型冠状病毒病（COVID-19）的常见并发症，为解开神经炎症和神经变性之间的关系提供了独特的机会。本综述探讨了从AME和COVID-19患者中吸取的经验教训。在从AME或COVID-19中恢复的患者中，持续性认知障碍越来越多地被认识到，但障碍的驱动因素在很大程度上仍然未知。临床观察、神经影像学和生物流体生物标志物以及病理学研究表明，急性神经炎症的严重程度、随后的神经变性和疾病相关发病率之间存在联系。来自AME和COVID-19患者的数据为关键假设提供了信息，这些假设可能通过未来的研究进行评估，这些研究将在大量康复患者中纳入神经炎症和神经变性的纵向生物标志物。这些研究的结果可能会为AME和COVID-19患者的认知障碍提供信息，并在年龄相关神经退行性疾病患者中具有潜在的诊断和治疗应用。
Does neuroinflammation promote neurodegeneration? Does neurodegeneration promote neuroinflammation? Or, is the answer to both questions, yes? These questions have proven challenging to answer in patients with typical age-related neurodegenerative diseases in whom the onset of neuroinflammation and neurodegeneration are largely unknown. Patients recovering from diseases associated with abrupt-onset neuroinflammation, including rare forms of antibody-mediated encephalitis (AME) and common complications of novel coronavirus disease 2019 (COVID-19), provide a unique opportunity to untangle the relationship between neuroinflammation and neurodegeneration. This review explores the lessons learned from patients with AME and COVID-19. Persistent cognitive impairment is increasingly recognized in patients recovering from AME or COVID-19, yet the drivers of impairment remain largely unknown. Clinical observations, neuroimaging and biofluid biomarkers, and pathological studies imply a link between the severity of acute neuroinflammation, subsequent neurodegeneration, and disease-associated morbidity. Data from patients with AME and COVID-19 inform key hypotheses that may be evaluated through future studies incorporating longitudinal biomarkers of neuroinflammation and neurodegeneration in larger numbers of recovering patients. The results of these studies may inform the contributors to cognitive impairment in patients with AME and COVID-19, with potential diagnostic and therapeutic applications in patients with age-related neurodegenerative diseases.
影响因子：
3.3
作者：
Day GS;Gordon BA;Bucelli RC;Perrin RJ;Lopez-Chiriboga AS;Ances BM
通讯作者：
Ances BM