POLE REGION DEPENDENT REPRESSION OF THE DROSOPHILA GAP GENE KRUPPEL BY MATERNAL GENE-PRODUCTS
POLE REGION DEPENDENT REPRESSION OF THE DROSOPHILA GAP GENE KRUPPEL BY MATERNAL GENE-PRODUCTS
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DOI：
10.1016/0092-8674(87)90124-3
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发表时间：
1987-11-20
期刊：
影响因子：
64.5
通讯作者：
JACKLE, H
中科院分区：
文献类型：
--
作者：
GAUL, U;JACKLE, H
我们检查了突变体中间隙基因 Krueppel (Kr) 的蛋白质结构域，该结构域影响沿果蝇胚胎纵轴的片段模式不同区域的建立。我们的数据表明，Kr 为在胚盘阶段建立“中心”模式元素提供了线索，并且 Kr 活性由作用于两极的母体效应基因控制。 Kr 蛋白结构域的形成可能涉及 Kr 基因表达的普遍激活，然而，该激活受到母体前部和后部模式组织者基因作用的区域特异性抑制的限制。此外，Kr蛋白结构域的形成取决于与Kr结构域相邻的间隙基因的活性，但它独立于从属配对规则基因的活性。
We examined the protein domain of the gap gene Krueppel (Kr) in mutants that affect the establishment of different regions of the segment pattern along the longitudinal axis of the Drosophila embryo. Our data suggest that Kr provides cues for establishing the "central" pattern elements at the blastoderm stage, and that Kr activity is controlled by maternal effect genes acting at the poles. The formation of the Kr protein domain may involve ubiquitous activation of Kr gene expression which, however, is limited by region-specific repression through the action of the maternal anterior and posterior pattern organizer genes. In addition, the formation of the Kr protein domain depends on the activity of gap genes acting adjacent to the Kr domain, but it is independent of subordinate pair-rule gene activities.