Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites.
Dragmacidin G, a Bioactive Bis-Indole Alkaloid from a Deep-Water Sponge of the Genus Spongosorites.
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DOI：
10.3390/md15010016
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发表时间：
2017-01-11
期刊：
影响因子：
5.4
通讯作者：
Rohde KH
中科院分区：
文献类型：
--
作者：
Wright AE;Killday KB;Chakrabarti D;Guzmán EA;Harmody D;McCarthy PJ;Pitts T;Pomponi SA;Reed JK;Roberts BF;Rodrigues Felix C;Rohde KH
海绵属的深水海绵产生了一种双吲哚生物碱，我们将其命名为dragmacidin G。Dragmacidin G首先由我们在专利文献中报道，最近由Hitora等报道来自Lipastrotheya属海绵。Dragmacidin G是该系列化合物中第一个具有连接两个吲哚环的吡嗪环的化合物。它也有一个罕见的N-（2-巯基乙基）-胍侧链。Dragmacidin G显示出广谱的生物活性，包括抑制耐甲氧西林金黄色葡萄球菌、结核分枝杆菌、恶性疟原虫和一组胰腺癌细胞系。
A deep-water sponge of the genus Spongosorites has yielded a bis-indole alkaloid which we have named dragmacidin G. Dragmacidin G was first reported by us in the patent literature and has recently been reported by Hitora et al. from a sponge of the genus Lipastrotheya. Dragmacidin G is the first in this series of compounds to have a pyrazine ring linking the two indole rings. It also has a rare N-(2-mercaptoethyl)-guanidine side chain. Dragmacidin G shows a broad spectrum of biological activity including inhibition of methicillin-resistant Staphylococcus aureus, Mycobacterium tuberculosis, Plasmodium falciparum, and a panel of pancreatic cancer cell lines.