COMPARISON OF 2 AMIDES AS BACKBONE REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGODEOXYNUCLEOTIDES
COMPARISON OF 2 AMIDES AS BACKBONE REPLACEMENT OF THE PHOSPHODIESTER LINKAGE IN OLIGODEOXYNUCLEOTIDES
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DOI：
10.1016/s0040-4039(00)77069-9
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发表时间：
1994-07-18
影响因子：
1.8
通讯作者：
DEMESMAEKER, A
中科院分区：
文献类型：
--
作者：
LEBRETON, J;WALDNER, A;DEMESMAEKER, A
两种异构酰胺修饰1和2在RNA/DNA双链体的解链温度上显示出类似的效果，当它们取代DNA链中的天然磷酸二酯键时。介绍了酰胺二聚体1的合成。
The two isomeric amide modifications 1 and 2 show similar effects on the melting temperature of RNA/DNA duplexes, when they replace the natural phosphodiester linkage in the DNA strand. The synthesis of the amide dimer 1 is presented.