Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas.
Rorgamma (Rorc) is a common integration site in type B leukemogenic virus-induced T-cell lymphomas.
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Rorgamma (Rorc) 是 B 型白血病病毒诱导的 T 细胞淋巴瘤中常见的整合位点。
作者：
D. Broussard;M. Lozano;J. Dudley
逆转录病毒B型白血病病毒（TBLV）在小鼠中引起t细胞淋巴瘤。我们已经在19%的tblv诱导肿瘤中发现Rorgamma位点为整合位点。一种或多种Rorgamma亚型在bb0 - 77%的肿瘤中过表达，可以补充c-myc过表达的凋亡效应。
The retrovirus type B leukemogenic virus (TBLV) causes T-cell lymphomas in mice. We have identified the Rorgamma locus as an integration site in 19% of TBLV-induced tumors. Overexpression of one or more Rorgamma isoforms in >77% of the tumors tested may complement apoptotic effects of c-myc overexpression.