The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response
The nucleoporin 153, a novel factor in double-strand break repair and DNA damage response
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DOI：
10.1038/onc.2011.638
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发表时间：
2012-11-01
期刊：
影响因子：
8
通讯作者：
Soutoglou, E.
中科院分区：
文献类型：
--
作者：
Lemaitre, C.;Fischer, B.;Soutoglou, E.
DNA修复对于维持基因组完整性至关重要，修复过程中不同步骤的缺陷与癌症和衰老有关。DNA修复是如何在高度区隔化的细胞核中进行空间和暂时组织的，以及不同的核区隔是否以不同的方式调节修复效率是一个长期存在的问题。越来越多的证据表明核孔复合物参与酵母双链断裂（DSBs）的修复。在这里，我们发现人类核孔蛋白153 （NUP153）在dsb的修复和DNA损伤检查点的激活中起作用。我们探索了NUP153的作用机制，并提出了其作为癌症治疗新靶点的潜力。
DNA repair is essential in maintaining genome integrity and defects in different steps of the process have been linked to cancer and aging. It is a long lasting question how DNA repair is spatially and temporarily organized in the highly compartmentalized nucleus and whether the diverse nuclear compartments regulate differently the efficiency of repair. Increasing evidence suggest the involvement of nuclear pore complexes in repair of double-strand breaks (DSBs) in yeast. Here, we show that the human nucleoporin 153 (NUP153) has a role in repair of DSBs and in the activation of DNA damage checkpoints. We explore the mechanism of action of NUP153 and we propose its potential as a novel therapeutic target in cancers.