Triphenylphosphine-Catalyzed Diastereoselective Addition of Oxazolones to Isatin-Derived Ketimines: Construction of Vicinal N-Substituted Quaternary Stereocenters
Triphenylphosphine-Catalyzed Diastereoselective Addition of Oxazolones to Isatin-Derived Ketimines: Construction of Vicinal N-Substituted Quaternary Stereocenters
复制标题
三苯膦催化恶唑啉酮与靛红衍生酮亚胺的非对映选择性加成：邻位 N-取代的季立构中心的构建
DOI：
10.1002/ajoc.201900107
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发表时间：
2019
影响因子：
2.7
通讯作者：
Jiang Xianxing
中科院分区：
文献类型：
--
作者：
Tong Pei;Li Ying;Zhang Yuan;Jiang Xianxing
本文中，已经开发了4-取代的恶唑酮与靛红衍生的酮亚胺的有机催化和高度非对映选择性加成。该方案提供了多种含有密集的邻位N-取代的四级立体中心的氨基羟吲哚-恶唑酮加合物。在温和的反应条件下，得到了良好的产率和优良的非对映选择性。
Herein, an organocatalytic and highly diastereoselective addition of 4‐substituted oxazolones to isatin‐derived ketimines has been developed. This protocol provides a variety of aminooxindole‐oxazolone adducts containing congested vicinalN‐substituted quaternary stereogenic centers. Good yields and excellent diastereoselectivity were obtained under mild reaction conditions.