Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine
Hepatitis C augments cognitive deficits associated with HIV infection and methamphetamine
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DOI：
10.1212/01.wnl.0000158328.26897.0d
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发表时间：
2005-04-26
期刊：
影响因子：
9.9
通讯作者：
Grant, I
中科院分区：
文献类型：
--
作者：
Cherner, M;Letendre, S;Grant, I
目的：探讨丙型肝炎病毒 (HCV) 感染对合并 HIV 感染或甲基苯丙胺 (METH) 依赖的个体神经认知功能障碍的影响。方法：对 430 名研究参与者的神经认知功能进行了检查，这些参与者要么是正常对照，要么有 HCV 感染、HIV 感染、METH 依赖史或这些因素的组合（存在认知缺陷的风险）。结果：整体和特定领域神经心理 (NP) 损伤的发生率随着危险因素数量的增加而增加。 HCV 血清状态是全球和学习、抽象和运动技能领域 NP 表现的重要预测因子，具有信息处理速度加快和回忆延迟的趋势。 HCV 血清状态不能预测注意力/工作记忆或语言流畅性的得分。结论：丙型肝炎病毒感染导致 HIV 感染者和兴奋剂依赖人群中观察到的神经心理缺陷。
Objective: To examine the contribution of hepatitis C virus (HCV) infection to neurocognitive dysfunction in individuals with comorbid HIV infection or methamphetamine (METH) dependence. Methods: Neurocognitive functioning was examined in 430 study participants who were either normal controls or had HCV infection, HIV infection, history of METH dependence, or combinations of these factors as risks for cognitive deficits. Results: Rates of global and domain-specific neuropsychological (NP) impairment increased with the number of risk factors. HCV serostatus was a significant predictor of NP performance both globally and in the areas of learning, abstraction, and motor skills, with trends in speeded information processing and delayed recall. HCV serostatus did not predict scores in attention/working memory or verbal fluency. Conclusion: Hepatitis C virus infection contributes to the neuropsychological deficits observed among HIV-infected and stimulant-dependent populations.