Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D
Similar rate of disease progression among individuals infected with HIV-1 genetic subtypes A-D
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DOI：
10.1097/00002030-199905280-00005
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发表时间：
1999-05-28
期刊：
影响因子：
3.8
通讯作者：
Albert, J
中科院分区：
文献类型：
--
作者：
Alaeus, A;Lidman, K;Albert, J
目的：HIV-1的特点是高度遗传变异，可分为至少10种不同的遗传亚型。本研究的目的是调查疾病进展率是否表现出亚型特异性差异。设计：调查分为两部分；其中一项研究对 49 名非洲人与 49 名瑞典人进行了比较，无论感染病毒的亚型如何；另一项研究对 126 名感染不同基因亚型的个体（28 名 A 亚型、59 名 B 亚型、21 名 C 亚型和 18 名 D 亚型）进行了比较。方法：CD4 细胞计数、CD4 细胞下降率、血浆 HIV-1 RNA 水平、临床状态和抗病毒治疗治疗进行了前瞻性和回顾性记录。 HIV-1亚型之前是通过对env基因V3结构域进行直接测序来确定的。结果：在2年的观察期内，非洲人和瑞典人的CD4细胞下降率或临床疾病进展没有显着差异。同样，在 44 个月的平均观察期内，感染 A、B、C 或 D 亚型的个体之间的 CD4 细胞下降率、临床进展或血浆 HIV-1 RNA 水平没有差异。结论：病毒的遗传亚型和宿主的种族似乎都不是疾病进展的主要决定因素。 (C) 1999 年利平科特·威廉姆斯和威尔金斯。
Objective: HIV-1 is characterized by a high degree of genetic variation and can be divided into at least 10 distinct genetic subtypes. The purpose of this study was to investigate whether the rate of disease progression shows subtype-specific differences.Design: The investigation was divided into two parts; one study in which 49 ethnic Africans were compared with 49 ethnic Swedes irrespective of the subtype of the infecting virus, and a second study in which 126 individuals infected with different genetic subtypes (28 with subtype A, 59 with subtype B, 21 with subtype C and 18 with subtype D) were compared.Methods: CD4 cell counts, the rate of CD4 cell decline, plasma HIV-1 RNA levels, clinical status and antiviral treatment were prospectively and retrospectively recorded. The HIV-1 subtype had previously been determined by direct sequencing of the V3 domain of the env gene.Results: There were no significant differences in the rate of CD4 cell decline or clinical disease progression between Africans and Swedes over an observation period of 2 years. Similarly, there were no differences in the rate of CD4 cell decline, clinical progression or plasma HIV-1 RNA levels between individuals infected with subtypes A, B, C or D over a mean observation period of 44 months.Conclusion: Neither the genetic subtype of the virus nor the ethnicity of the host appear to be major determinants of disease progression. (C) 1999 Lippincott Williams & Wilkins.