Strain-specific sensitivity to MPTP of C57BL/6 and BALB/c mice is age dependent
Strain-specific sensitivity to MPTP of C57BL/6 and BALB/c mice is age dependent
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DOI：
10.1097/wnr.0b013e32832aa95b
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发表时间：
2009-05-06
期刊：
影响因子：
1.7
通讯作者：
Sistrunk, Shannon C.
中科院分区：
文献类型：
--
作者：
Filipov, Nikolay M.;Norwood, Allison B.;Sistrunk, Shannon C.
对成年（2月龄至4月龄）雄性C57 BL/6小鼠（MPTP敏感）给予MPTP（1-甲基-4-苯基-1，2，3，6-四氢吡啶）是一种有价值的帕金森病模型。在相当的年龄，其他菌株，如BALB/c，受MPTP（MPTP耐药）的影响最小。然而，在MPTP抗性菌株中，在整个老化过程中对MPTP的抗性的维持尚未研究。在这里，我们表明，如前所述，1个月和18个月大的C57 BL/6小鼠是最少和最敏感的MPTP，分别。正如预期的那样，MPTP对年轻（1个月和3个月大）的BALB/c小鼠没有影响，但它显著降低了老年（10个月和18个月大）BALB/c小鼠的纹状体多巴胺。这些数据表明，对MPTP的敏感性是年龄依赖性的，并且来自MPTP抗性品系的小鼠随着年龄的增长而失去其抗性。NeuroReport 20：713-717（C）2009年威科健康垂直酒吧Lippincott威廉姆斯&威尔金斯。
Administration of MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) to adult (2-month to 4-month-old) male C57BL/6 mice (MPTP-sensitive) is a valuable Parkinson's disease model. At comparable age, other strains, such as BALB/c, are minimally affected by MPTP (MPTP-resistant). However, the maintenance of resistance to MPTP throughout aging in MPTP-resistant strains has not been studied. Here, we show that, as previously reported, 1-month and 18-month-old C57BL/6 mice are least and most sensitive to MPTP, respectively. MPTP as expected, did not affect the younger (1-month and 3-month-old) BALB/c mice, but it markedly decreased striatal dopamine in the older (10-month and 18-month-old) BALB/c mice. These data suggest that the sensitivity to MPTP is age dependent and that mice from an MPTP-resistant strain lose their resistance as they age. NeuroReport 20:713-717 (C) 2009 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.