Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome.
Androgen receptor roles in insulin resistance and obesity in males: the linkage of androgen-deprivation therapy to metabolic syndrome.
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作者：
Yu IC;Lin HY;Sparks JD;Yeh S;Chang C
前列腺癌是男性最常见的恶性肿瘤之一。雄激素剥夺治疗（ADT）是男性晚期前列腺癌的一线治疗和基本管理，以抑制雄激素/雄激素受体（AR）信号转导功能。ADT可有效改善癌症症状并延长生存期。然而，流行病学和临床研究支持这样的观点，即男性睾酮缺乏导致代谢综合征的发展，增加心血管疾病的风险。雄激素/AR信号调节男性代谢稳态的潜在机制是复杂的，在这篇综述中，我们讨论了由AR信号介导的将ADT与代谢综合征联系起来的分子机制。来自各种AR敲除小鼠模型的结果揭示了参与代谢调节的组织特异性AR信号传导。这些数据表明，应尽早采取措施管理与接受ADT的PCa患者相关的代谢并发症，这可以通过组织选择性调节AR信号传导和胰岛素增敏剂治疗来实现。
Prostate cancer (PCa) is one of the most frequently diagnosed malignancies in men. Androgen-deprivation therapy (ADT) is the first-line treatment and fundamental management for men with advanced PCa to suppress functions of androgen/androgen receptor (AR) signaling. ADT is effective at improving cancer symptoms and prolonging survival. However, epidemiological and clinical studies support the notion that testosterone deficiency in men leads to the development of metabolic syndrome that increases cardiovascular disease risk. The underlying mechanisms by which androgen/AR signaling regulates metabolic homeostasis in men are complex, and in this review, we discuss molecular mechanisms mediated by AR signaling that link ADT to metabolic syndrome. Results derived from various AR knockout mouse models reveal tissue-specific AR signaling that is involved in regulation of metabolism. These data suggest that steps be taken early to manage metabolic complications associated with PCa patients receiving ADT, which could be accomplished using tissue-selective modulation of AR signaling and by treatment with insulin-sensitizing agents.
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DOI：
10.1056/nejmoa1000485
发表时间：
2010-07-08
期刊：
The New England journal of medicine
影响因子：
--
作者：
Basaria S;Coviello AD;Travison TG;Storer TW;Farwell WR;Jette AM;Eder R;Tennstedt S;Ulloor J;Zhang A;Choong K;Lakshman KM;Mazer NA;Miciek R;Krasnoff J;Elmi A;Knapp PE;Brooks B;Appleman E;Aggarwal S;Bhasin G;Hede-Brierley L;Bhatia A;Collins L;LeBrasseur N;Fiore LD;Bhasin S
通讯作者：
Bhasin S
影响因子：
5.3
作者：
Akishita, Masahiro;Hashimoto, Masayoshi;Ouchi, Yasuyoshi
通讯作者：
Ouchi, Yasuyoshi
DOI：
10.1016/j.ijrobp.2004.08.024
发表时间：
2005-04-01
影响因子：
7
作者：
Beyer, DC;McKeough, T;Thomas, T
通讯作者：
Thomas, T
DOI：
10.1097/mco.0b013e32832a3d79
发表时间：
2009-05-01
影响因子：
3.1
作者：
Bhasin, Shalender;Jasuja, Ravi
通讯作者：
Jasuja, Ravi
影响因子：
7.7
作者：
Accili, D
通讯作者：
Accili, D