Association of ambient fine particles with out-of-hospital cardiac arrests in New York City.
Association of ambient fine particles with out-of-hospital cardiac arrests in New York City.
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DOI：
10.1093/aje/kwq217
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发表时间：
2010-10
影响因子：
5
通讯作者：
R. Silverman;Kazuhiko Ito;J. Freese;B. Kaufman;Danilynn De Claro;James Braun;D. Prezant
中科院分区：
文献类型：
--
作者：
R. Silverman;Kazuhiko Ito;J. Freese;B. Kaufman;Danilynn De Claro;James Braun;D. Prezant
心血管疾病的发病率与颗粒物（PM）空气污染有关，尽管污染物与心脏骤停猝死之间的关系尚未确定。本研究调查了纽约市院外心脏骤停与细颗粒物（空气动力学直径≤2.5 μm，或PM（2.5））、臭氧、二氧化氮、二氧化硫和一氧化碳之间的关系。作者分析了2002-2006年期间8,216例院外心脏骤停的主要心脏病因。进行时间序列和病例交叉分析，控制季节，一周中的一天，同一天，延迟/表观温度。心脏骤停的风险增加（相对风险（RR）= 1.06，95%置信区间（CI）：1.02，1.10）和病例交叉（RR = 1.04，95% CI：0.99,1.08）PM分析（2.5）0天和1天的滞后平均值增加了10 μg/m³，在暖季这种关联显著（RR = 1.09，95% CI：1.03，1.15），而非寒冷季节（RR = 1.01，95% CI：0.95，1.07）。心脏骤停与其他污染物的关联较弱。这些发现与PM的急性心血管效应研究一致，支持PM（2.5）和院外心脏骤停之间的联系。由于很少有人能在逮捕中幸存下来，空气污染控制可能有助于防止未来的心血管死亡率。
Cardiovascular morbidity has been associated with particulate matter (PM) air pollution, although the relation between pollutants and sudden death from cardiac arrest has not been established. This study examined associations between out-of-hospital cardiac arrests and fine PM (of aerodynamic diameter ≤2.5 μm, or PM(2.5)), ozone, nitrogen dioxide, sulfur dioxide, and carbon monoxide in New York City. The authors analyzed 8,216 out-of-hospital cardiac arrests of primary cardiac etiology during the years 2002-2006. Time-series and case-crossover analyses were conducted, controlling for season, day-of-week, same-day, and delayed/apparent temperature. An increased risk of cardiac arrest in time-series (relative risk (RR) = 1.06, 95% confidence interval (CI): 1.02, 1.10) and case-crossover (RR = 1.04, 95% CI: 0.99, 1.08) analysis for a PM(2.5) increase of 10 μg/m³ in the average of 0- and 1-day lags was found. The association was significant in the warm season (RR = 1.09, 95% CI: 1.03, 1.15) but not the cold season (RR = 1.01, 95% CI: 0.95, 1.07). Associations of cardiac arrest with other pollutants were weaker. These findings, consistent with studies implicating acute cardiovascular effects of PM, support a link between PM(2.5) and out-of-hospital cardiac arrests. Since few individuals survive an arrest, air pollution control may help prevent future cardiovascular mortality.