Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic chagasic cardiopathy in mice
Reinfections and Trypanosoma cruzi strains can determine the prognosis of the chronic chagasic cardiopathy in mice
复制标题
DOI：
10.1007/s00436-006-0425-3
复制
发表时间：
2007-05-01
影响因子：
2
通讯作者：
Paglini-Oliva, Patricia A.
中科院分区：
文献类型：
--
作者：
Bustamante, Juan M.;Novarese, Monica;Paglini-Oliva, Patricia A.
慢性恰加斯病是宿主和寄生虫之间相互作用的结果，产生不同的临床特征：从轻微的疾病到严重的心力衰竭。在本研究中，我们分析了克氏锥虫菌株和/或急性期的再感染是否确定了慢性期（感染后 135 天，d.p.i）的变化，这可以解释心脏病变的多样化演变。分别用 50 个克氏锥虫血液锥鞭毛体、Tulahuen 株 (n=80) 和分离株 SGO-Z12 (n=90) 感染白化瑞士小鼠 (n=170) 后，并在 10 d.p.i 和 20 d.p.i 时再次感染。研究了寄生虫血症、存活率、心电图、心脏 P 受体的亲和力和密度以及心脏的组织病理学。再次感染小鼠的寄生虫血症明显高于单次感染小鼠。 SGO-Z12感染组的存活率显着高于其他组（p
Chronic Chagas' disease represents the result of the interaction between the host and the parasite, producing different clinical features: from a mild disease to a severe heart failure. In the present investigation, we analyzed whether Trypanosoma cruzi strain and/or reinfections in the acute stage, determine changes in the chronic phase (135 days postinfection, d.p.i) that could explain the diverse evolution of cardiac lesions. After infection of albino Swiss mice (n= 170) with 50 blood trypomastigote of the T cruzi, strain Tulahuen (n=80) and the isolate SGO-Z12 (n=90), respectively, and reinfections at 10 and 20 d.p.i. Parasitemia, survival, electrocardiography, affinity and density of cardiac P-receptors and histopathology of the heart were studied. Parasitemias in reinfected mice were significantly higher than those in single-infected mice. Survival of SGO-Z12-infected group was significantly higher than the other groups (p