Periostin action in bone
Periostin action in bone
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DOI：
10.1016/j.mce.2015.12.014
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发表时间：
2016-09-05
影响因子：
4.1
通讯作者：
Ferrari, Serge
中科院分区：
文献类型：
--
作者：
Bonnet, Nicolas;Garnero, Patrick;Ferrari, Serge
骨膜蛋白是一种高度保守的基质细胞蛋白，与昆虫细胞粘附分子fasciclin 1具有高度同源性。骨膜蛋白在包括骨骼在内的广泛组织中表达，在骨骼中它既作为骨基质的结构分子，又作为通过整联蛋白受体和Wnt-β-连环蛋白途径的信号分子，从而刺激成骨细胞功能和骨形成。骨膜蛋白基因敲除小鼠的发展已经允许阐明骨膜蛋白对牙本质形成和骨形成的关键作用，以及对骨骼对机械负荷和甲状旁腺激素的反应。循环骨膜蛋白作为一种潜在的临床生物标志物的用途已在不同的非骨骼条件下进行了探索。这些包括癌症，更具体地说，在转移过程中，呼吸系统疾病，如哮喘，肾衰竭，肾损伤和心肌梗死。在绝经后骨质疏松症中，血清水平已被证明可以预测骨质疏松症的风险，更具体地说是非椎骨性骨质疏松症，与骨密度无关。由于其优先定位于皮质骨和骨膜组织，可以推测，血清骨膜蛋白可能是皮质骨代谢的标志物，但显然需要进一步的研究。(C)2016爱思唯尔爱尔兰有限公司版权所有。
Periostin is a highly conserved matricellular protein that shares close homology with the insect cell adhesion molecule fasciclin 1. Periostin is expressed in a broad range of tissues including the skeleton, where it serves both as a structural molecule of the bone matrix and a signaling molecule through integrin receptors and Wnt-beta-catenin pathways whereby it stimulates osteoblast functions and bone formation. The development of periostin null mice has allowed to elucidate the crucial role of periostin on dentinogenesis and osteogenesis, as well as on the skeletal response to mechanical loading and parathyroid hormone. The use of circulating periostin as a potential clinical biomarker has been explored in different non skeletal conditions. These include cancers and more specifically in the metastasis process, respiratory diseases such as asthma, kidney failure, renal injury and cardiac infarction. In postmenopausal osteoporosis, serum levels have been shown to predict the risk of fracture-more specifically non-vertebral- independently of bone mineral density. Because of its preferential localization in cortical bone and periosteal tissue, it can be speculated that serum periostin may be a marker of cortical bone metabolism, although additional studies are clearly needed. (C) 2016 Elsevier Ireland Ltd. All rights reserved.