Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers
Psychiatric symptoms in preclinical behavioural-variant frontotemporal dementia in MAPT mutation carriers
复制标题
DOI：
10.1136/jnnp-2017-317263
复制
发表时间：
2018-05-01
影响因子：
11
通讯作者：
Huey, Edward D.
中科院分区：
文献类型：
--
作者：
Cheran, Gayathri;Silverman, Hannah;Huey, Edward D.
目的探讨行为变异性额颞叶痴呆（bvFTD）临床前和早期的精神症状，bvFTD是一种神经退行性疾病，其症状与精神疾病重叠，常被误认为精神疾病。和46个家族性非携带者对照。目前的精神症状，举报人报告的症状和精神疾病的终身患病率进行了评估，精神疾病的诊断和统计手册，第四版（DSM-IV）和神经精神病量表问卷。Fisher精确检验用于比较携带者和非携带者的6种DSM-IV疾病的终生患病率：重度抑郁症、惊恐发作、酒精滥用、广泛性焦虑症、惊恐障碍和未另行说明的抑郁症。其他DSM-IV疾病在我们的样本组间比较的患病率不足，但report.Results非载体有更大的情绪和焦虑症的患病率比一般参考人群的报告。临床前携带者的心境障碍和焦虑障碍的终生患病率低于非携带者，但抑郁障碍除外，一种非典型综合征，包括临床上显著的抑郁症状，不符合重度抑郁症的标准。结论研究结果表明，紧急bvFTD的早期精神症状可能表现为情绪迟钝或情绪变化，不完全符合DSM的标准。明确的情绪障碍
Objective To characterise psychiatric symptoms in preclinical and early behavioural-variant frontotemporal dementia (bvFTD), a neurodegenerative disorder whose symptoms overlap with and are often mistaken for psychiatric illness.Methods The present study reports findings from a systematic, global, prospective evaluation of psychiatric symptoms in 12 preclinical carriers of pathogenic MAPT mutations, not yet meeting bvFTD diagnostic criteria, and 46 familial non-carrier controls. Current psychiatric symptoms, informant-reported symptoms and lifetime prevalence of psychiatric disorders were assessed with The Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) and the Neuropsychiatric Inventory Questionnaire. Fisher exact test was used to compare carriers and non-carriers' lifetime prevalence of six DSM-IV disorders: major depressive disorder, panic attacks, alcohol abuse, generalised anxiety disorder, panic disorder, and depressive disorder not otherwise specified. Other DSM-IV disorders had insufficient prevalence across our sample for between-group comparisons, but are reported.Results Non-carriers had greater prevalence of mood and anxiety disorders than has been reported for a general reference population. Preclinical carriers had lower lifetime prevalence of mood and anxiety disorders than non-carriers, except for depressive disorder not otherwise specified, an atypical syndrome comprising clinically significant depressive symptoms which fail to meet criteria for major depressive disorder.Conclusion Findings suggest that early psychiatric symptoms of emergent bvFTD may manifest as emotional blunting or mood changes not cleanly conforming to criteria for a DSM-defined mood disorder.