Multispectral optoacoustic tomography of systemic sclerosis
Multispectral optoacoustic tomography of systemic sclerosis
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DOI：
10.1002/jbio.201800155
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发表时间：
2018-11-01
影响因子：
2.8
通讯作者：
Wildgruber, Moritz
中科院分区：
文献类型：
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作者：
Masthoff, Max;Helfen, Anne;Wildgruber, Moritz
本研究旨在评价混合超声/多光谱光声断层扫描（MSOT）评估系统性硬化症（SSc）微血管功能障碍的临床可行性。应用手持式US/MSOT成像系统对诊断为SSc的患者（n = 7）和健康志愿者（n = 8）进行成像。分析双手皮下手指组织（每例受试者8根手指，共120根手指）的脱氧（HbR）、氧合（HbO（2））和总血红蛋白（HbT）的半定量MSOT值，并用于评估疾病活动性（进展vs稳定）。分组资料比较采用单因素巢式方差分析、Tukey事后检验和t检验进行统计学分析，SSc患者手指皮下组织的HbO（2）MSOT值显著低于对照组（26.16 +/- 0.71 vs 38.2 +/- 1.54，P = 0.023）和HbT（55.92 +/- 1.62 vs 72.46 +/- 1.90，P = 0.018）。与病情稳定的患者和健康志愿者相比，进行性SSc患者的MSOT值显著降低。这项初步研究显示了MSOT成像作为疾病活动标志物解决SSc微血管功能障碍的可行性。通过提供其他成像方式无法显示的生物组织特性，MSOT可能有助于非侵入性地对SSc进行分级并监测早期治疗反应。
The study aimed to evaluate the clinical feasibility of hybrid ultrasound/multispectral optoacoustic tomography (MSOT) for assessing microvascular dysfunction in systemic sclerosis (SSc). A handheld US/MSOT imaging system was applied for imaging patients diagnosed with SSc (n = 7) and healthy volunteers (n = 8). Semiquantitative MSOT values for deoxygenated (HbR), oxygenated (HbO(2)) and total haemoglobin (HbT) were analysed for subcutaneous finger tissue of both hands (8 fingers per subject, 120 fingers in total) and used to assess disease activity (progressive vs stable). Grouped data were compared by one-way nested analysis of variance, Tukey post-hoc test as well as student's t test were used for statistical analysis.Subcutaneous finger tissue of patients with SSc provided significantly lower MSOT values for HbO(2) (26.16 +/- 0.71 vs 38.2 +/- 1.54, P =.023) and HbT (55.92 +/- 1.62 vs 72.46 +/- 1.90, P =.018) compared to healthy volunteers. Patients with progressive SSc had significantly lower MSOT values compared to patients with stable disease and healthy volunteers.This pilot study shows the feasibility of MSOT imaging to resolve microvascular dysfunction in SSc as a marker of disease activity. By providing biological tissue properties not revealed by other imaging modalities, MSOT might help to grade SSc non-invasively and monitor early therapy response.