Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox.
Multidisciplinary study of the secondary immune response in grandparents re-exposed to chickenpox.
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DOI：
10.1038/s41598-017-01024-8
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发表时间：
2017-04-24
影响因子：
4.6
通讯作者：
Beutels P
中科院分区：
文献类型：
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作者：
Ogunjimi B;Van den Bergh J;Meysman P;Heynderickx S;Bergs K;Jansens H;Leuridan E;Vorsters A;Goossens H;Laukens K;Cools N;Van Tendeloo V;Hens N;Van Damme P;Smits E;Beutels P
再次接触水痘可能会提高水痘带状疱疹病毒（VZV）的免疫力在老年人。这种继发性免疫应答被假设为提供针对带状疱疹的保护。我们对36名成年人在再次暴露于水痘后的一年内进行了纵向采样。对所得的183份样品和14份对照样品进行VZV特异性T细胞免疫和抗体滴度评估。VZV特异性CD 4 + IL-2产生T细胞的百分比在再次暴露的祖父母中增加，与对照参与者相比，在再次暴露后长达9个月。使用纵向混合建模方法，我们发现25%和17%的再次暴露的祖父母分别显示VZV特异性CD 4 + IL-2产生T细胞和VZV特异性抗体的增强。抗体加强只发生在巨细胞病毒（CMV）IgG阳性的参与者。CMV IgG阳性的参与者也具有较高的VZV IE62特异性CD 4 + IFN-γ产生T细胞百分比和VZV特异性抗体滴度。再次暴露于水痘的保护作用可能有限，因为仅在17-25%的VZV再次暴露的祖父母中发生了加强，并且不到一年。
Re-exposure to chickenpox may boost varicella-zoster virus (VZV) immunity in the elderly. This secondary immune response is hypothesized to confer protection against herpes zoster. We longitudinally sampled 36 adults over the course of one year after re-exposure to chickenpox. The resulting 183 samples and those of 14 controls were assessed for VZV-specific T-cell immunity and antibody titres. The percentages of VZV-specific CD4+ IL-2-producing T-cells were increased in re-exposed grandparents compared to control participants up to 9 months after re-exposure. Using a longitudinal mixture modelling approach, we found that 25% and 17% of re-exposed grandparents showed a boosting of VZV-specific CD4+ IL-2-producing T-cells and VZV-specific antibodies, respectively. The antibody boosting occurred exclusively in cytomegalovirus (CMV) IgG-positive participants. CMV IgG-positive participants also had higher VZV IE62-specific CD4+ IFN-γ-producing T-cell percentages and VZV-specific antibody titres. The protective effect of re-exposure to chickenpox is likely limited, as boosting only occurred in 17–25% of the VZV re-exposed grandparents and for less than one year.