S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.
S100A10, a novel biomarker in pancreatic ductal adenocarcinoma.
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DOI：
10.1002/1878-0261.12356
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发表时间：
2018-11
影响因子：
6.6
通讯作者：
Waisman DM
中科院分区：
文献类型：
--
作者：
Bydoun M;Sterea A;Liptay H;Uzans A;Huang WY;Rodrigues GJ;Weaver ICG;Gu H;Waisman DM
胰腺癌是最致命的癌症类型。目前治疗的有效性往往受到无法预测患者结果的阻碍。因此，开发早期检测和风险预测工具是改善结果和生活质量的关键。在这里，我们介绍了纤溶酶原受体S100A10作为一种新的预测生物标志物和胰腺肿瘤生长和侵袭的驱动程序。我们证明，S100A10 mRNA和蛋白质在人胰腺肿瘤中过表达相比，正常导管和非导管间质。S100A10 mRNA和甲基化状态可预测多个患者队列的总生存期和无复发生存期。S100A10的表达是由启动子甲基化和癌基因KRAS驱动的。S100A10敲低降低胰腺癌细胞系的表面纤溶酶原活化、侵袭性和体内生长。这些发现描述了S100A10作为胰腺癌生物标志物的临床和功能贡献。
Pancreatic cancer is arguably the deadliest cancer type. The efficacy of current therapies is often hindered by the inability to predict patient outcome. As such, the development of tools for early detection and risk prediction is key for improving outcome and quality of life. Here, we introduce the plasminogen receptor S100A10 as a novel predictive biomarker and a driver of pancreatic tumor growth and invasion. We demonstrated that S100A10 mRNA and protein are overexpressed in human pancreatic tumors compared to normal ducts and nonductal stroma. S100A10 mRNA and methylation status were predictive of overall survival and recurrence‐free survival across multiple patient cohorts. S100A10 expression was driven by promoter methylation and the oncogene KRAS. S100A10 knockdown reduced surface plasminogen activation, invasiveness, and in vivo growth of pancreatic cancer cell lines. These findings delineate the clinical and functional contribution of S100A10 as a biomarker in pancreatic cancer.
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实现癌症基因组数据的共同愿景。
DOI：
10.1056/nejmp1607591
发表时间：
2016-09-22
期刊：
The New England journal of medicine
影响因子：
--
作者：
Grossman RL;Heath AP;Ferretti V;Varmus HE;Lowy DR;Kibbe WA;Staudt LM
通讯作者：
Staudt LM
影响因子：
--
作者：
Jin, Bilian;Robertson, Keith D.
通讯作者：
Robertson, Keith D.
影响因子：
4.8
作者：
Choi, KS;Fogg, KD;Waisman, DM
通讯作者：
Waisman, DM
影响因子：
3.3
作者：
Bydoun, Moamen;Waisman, David M.
通讯作者：
Waisman, David M.
影响因子：
5.7
作者：
Ishikawa, M;Yoshida, K;Mano, H
通讯作者：
Mano, H