Serum uric acid level and risk for peripheral arterial disease: Analysis of data from the multiple risk factor intervention trial
Serum uric acid level and risk for peripheral arterial disease: Analysis of data from the multiple risk factor intervention trial
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DOI：
10.1177/0003319707303444
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发表时间：
2007-08-01
期刊：
影响因子：
2.8
通讯作者：
Krishnan, Eswar
中科院分区：
文献类型：
--
作者：
Baker, Joshua F.;Schumacher, H. Ralph;Krishnan, Eswar
尽管一些研究报道了高尿酸血症与冠状动脉疾病之间的关联，但对高尿酸血症和痛风对外周动脉疾病（PAD）风险的影响知之甚少。在一项多心血管危险因素干预的随机对照试验中，对283例PAD事件临床病例的数据进行了评估。将这些人的血清尿酸水平与研究期间未患PAD的人的血清尿酸水平进行比较。在调整传统血管危险因素的影响后，多因素logistic回归分析测量了与血清尿酸水平升高相关的PAD发生风险。年龄和吸烟与PAD的发展独立相关，比值比分别为1.08（95%可信区间[CI]， 1.06-1.09）和3.83 (95% CI, 2.49-5.91) /年。高尿酸血症（血清尿酸水平，> 7.0 mg/dL）是一个独立的危险因素，比值比为1.23，但估计的置信区间很宽（95% CI, 0.98-1.54）。在这个多变量模型中，痛风病史的比值比为1.33 （95% CI, 1.07-1.66）。血清尿酸水平与较高的PAD风险独立相关（但统计上不显著）。痛风性关节炎史是PAD发病率的独立且具有统计学意义的预测因子，即使在调整了潜在高尿酸血症的影响后也是如此。
Although several studies report an association between hyperuricemia and coronary artery disease, little is known about the effect of hyperuricemia and gout on the risk of peripheral arterial disease (PAD). Data on 283 incident clinical cases of PAD during a randomized controlled trial of multiple cardiovascular risk factor intervention are evaluated. The serum uric acid levels among these individuals are compared with those of individuals who did not develop PAD during the study period. Multivariate logistic regression analyses measure the risk of developing PAD associated with higher levels of serum uric acid after adjusting for the effect of traditional vascular risk factors. Age and smoking are independently associated with development of PAD, with odds ratios of 1.08 (95% confidence interval [CI], 1.06-1.09) and 3.83 (95% CI, 2.49-5.91) per year, respectively. Hyperuricemia (serum uric acid level, > 7.0 mg/dL) is an independent risk factor, with an odds ratio of 1.23, but the confidence interval of the estimate is wide (95% CI, 0.98-1.54). In this multivariate model, a history of gout was associated with an odds ratio of 1.33 (95% CI, 1.07-1.66). Serum uric acid level is independently associated with a higher (but statistically nonsignificant) risk of PAD. A history of gouty arthritis is an independent and statistically significant predictor of incidence of PAD even after adjustment for the effect of underlying hyperuricemia.