Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi.
Pattern of brain morphology in patients with schizophrenia and large cavum septi pellucidi.
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精神分裂症和大透明隔腔患者的脑形态学模式。
DOI：
10.1176/jnp.8.2.147
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发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Andreasen,NC
中科院分区：
文献类型：
--
作者：
Nopoulos,P;Swayze,V;Andreasen,NC
透明隔腔(CSP)是一种中线发育异常，在精神分裂症患者中发病率增加。CSP的病因可能与颞叶发育不全有关。这项研究评估了三组人的大脑变化模式：1)正常对照组，2)无大CSP的精神分裂症患者，3)有大CSP的精神分裂症患者。没有大的CSP的患者大脑、额叶和颞叶的总体积减少；有CSP异常的患者右-GT；左侧不对称更明显，仅限于左侧颞叶。这些发现表明，精神分裂症和大型CSP患者可能会表现出与没有这种异常的患者不同的脑形态紊乱模式。
Cavum septi pellucidi (CSP) is a midline developmental anomaly shown to have increased incidence in patients with schizophrenia. The etiology of CSP may involve dysgenesis of the temporal lobes. This study evaluated the pattern of brain changes in three groups: 1) normal control subjects, 2) schizophrenic subjects without large CSP, and 3) schizophrenic subjects with large CSP. Patients without large CSP had decreased total brain, frontal, and temporal lobe volumes; patients with the anomaly had more pronounced right> left asymmetry and volume decrement limited to the left temporal lobe. These findings indicate that patients with schizophrenia and large CSP may show a different pattern of disturbed brain morphology than patients without this abnormality.